Merck

SAB4200800

Sigma-Aldrich

Anti-Collagen, Type X antibody, Mouse monoclonal

clone COL-10, purified from hybridoma cell culture

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别名:
Anti-COL10A1
NACRES:
NA.41

生物来源

mouse

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

COL-10, monoclonal

形式

buffered aqueous solution

分子量

~60 kDa

species reactivity

deer, porcine, human

包装

antibody small pack of 25 μL

浓度

~1 mg/mL

technique(s)

immunoblotting: suitable
immunofluorescence: 5-10 μg/mL using human osteosarcoma SaOS-2 cells
immunohistochemistry: suitable

同位素/亚型

IgM

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... COL10A1(1300)

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此商品
SAB4200749SAB4200678C2456
antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified immunoglobulin

antibody form

ascites fluid

clone

COL-10, monoclonal

clone

FH-7A, monoclonal

clone

COL-1, monoclonal

clone

COL-1, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

-

mol wt

~60 kDa

mol wt

~70 kDa

mol wt

-

mol wt

-

species reactivity

deer, porcine, human

species reactivity

rat, human

species reactivity

pig, rat, human, deer, bovine

species reactivity

bovine, human, pig, rat, rabbit, deer

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一般描述

The extracellular matrix (ECM) found in the extracellular environment of all tissues and organs, provides the physical microenvironment for cells and a substrate for cell anchorage. It serves as a tissue scaffold and is a dynamic structure whose organization and composition modulate various cellular processes including cell proliferation, attachment, migration, differentiation and survival. The composition of the extracellular framework of all vertebrates is dominated by a Collagen protein family, each member with unique features suited for its function and location.

Type X collagen,also known as Collagen alpha-1(X) chain (COL10A1), is a product of hypertrophic chondrocytes. It shares a similar domain structure with type VIII collagen. In addition, both collagen types represent major components of hexagonal lattice structure, in which the collagen molecules link together by interactions involving the non-triple-helical end regions. Despite these similarities, a distinct tissue distribution has been found for these two molecules: type VIII collagen is distributed in various tissues, whereas type X is restricted to normal fetal hypertrophic cartilage in the growth zones of long bones, vertebrae and ribs and in adult (> 21 yr) thyroid cartilage. It is also found in bone fracture callus, osteoarthritic cartilage and chondrogenic neoplasms, and may be involved in cartilage mineralization. Type X collagen is non-fibrillar, but forms fine pericellular filaments in association with cartilage collagen. It interacts with matrix proteins, such as connexin V, chondrocalcein, collagen II and proteoglycans, as well as with Ca2+ . Mutations in this gene are associated with schmid metaphyseal chondroplasia (MCDS).

The development of antibodies against collagens has provided a powerful method for examining the distribution of these connective tissue proteins and for investigation of epithelial-mesenchymal interactions, tumorigenesis and basement membrane biology in ontogeny and epithelial differentiation.8 Antibodies that react specifically with collagen type X are useful for the study of specific differential tissue expression and the localization of collagen type X.

免疫原

Porcine collagen type X

应用

Monoclonal Anti-Collagen, Type X specifically recognizes native and denatured collagen type X. It does not recognize collagen types I, II, III, V, IX and XI. Reactivity has been observed with human, deer and porcine collagen type X. The antibody is recommended to use in various immunological techniques, including Immunoblotting (∼ 60 kDa in denatured-reduced preparation), Immunofluorescence and Immunohistochemistry.

外形

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

其他说明

This product is for R&D use only, not for drug, household, or other uses.

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Joanna J Moss et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(11), e22002-e22002 (2021-10-29)
Autophagy is a catabolic process responsible for the removal of waste and damaged cellular components by lysosomal degradation. It plays a key role in fundamental cell processes, including ER stress mitigation, control of cell metabolism, and cell differentiation and proliferation

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