Merck

SAB4300339

Sigma-Aldrich

Anti-BCL2 (Ab-56) antibody produced in rabbit

affinity isolated antibody

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别名:
Anti-B-cell CLL / lymphoma 2 antibody produced in rabbit, Anti-Bcl-2 antibody produced in rabbit
MDL编号:
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

antibody product type

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

~26 kDa

species reactivity

human

浓度

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

同位素/亚型

IgG

免疫原序列

(G-H-T-P-H)

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... BCL2(596)

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此商品
SAB4300340B3170HPA004899
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

ascites fluid

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

Bcl-2-100, monoclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

-

form

buffered aqueous glycerol solution

mol wt

~26 kDa

mol wt

~26 kDa

mol wt

antigen 26 kDa

mol wt

-

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一般描述

BCL2 (B-cell lymphoma 2) consists of pro- and antiapoptotic functions. It belongs to BCL2 family of proteins. It is mapped to chromosome 18q21.3 .

免疫原

Peptide sequence around aa. 54-58 (G-H-T-P-H), according to the protein BCL2.

应用

Anti-BCL2 (Ab-56) antibody has been used in western blotting .

生化/生理作用

Overexpression of BCL2 (B-cell lymphoma 2) results in poor clinical predictions in diffuse large B-cell lymphoma (DLBCL). It plays an important role in the growth and progression of cancer.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer
Yang J, et al.
Biochemical and Biophysical Research Communications (2015)
CD164 regulates proliferation and apoptosis by targeting PTEN in human glioma
Tu M, et al.
Molecular Medicine Reports (2017)
BCL2 expression in DLBCL: reappraisal of immunohistochemistry with new criteria for therapeutic biomarker evaluation
Tsuyama N, et al.
Blood (2017)
miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer
Zhang N, et al.
Oncology Letters (2016)
BCL2 genotypes and prostate cancer survival
Renner W, et al.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [Et Al] (2017)

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