SAB4301658

Anti-CSPG4

affinity isolated antibody

• 别名: HMW-MAA, MCSP, MCSPG, MSK16, NG2
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 抗体形式: affinity isolated antibody
• antibody product type: primary antibodies
• 克隆: polyclonal
• 形式: buffered aqueous glycerol solution
• species reactivity: human, mouse, rat
• technique(s): immunohistochemistry: 1:20-1:100; western blot: 1:500-1:2000
• 登记号: NP_001888
• UniProt登记号: Q6UVK1
• 运输: wet ice
• 储存温度: −20°C
• Gene Information: human ... CSPG4(1464)

说明

一般描述

Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.

免疫原

Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4

生化/生理作用

Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.

特点和优势

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外形

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 1
• 闪点(F): Not applicable
• 闪点(C): Not applicable