Merck

SAB4503882

Sigma-Aldrich

Anti-phospho-IKK-α (pSer176) /IKK-β (pSer177) antibody produced in rabbit

affinity isolated antibody

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NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

antigen 84 kDa

种属反应性

rat, human, mouse

浓度

~1 mg/mL

技术

ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

phosphorylation (pSer176/pSer177)

基因信息

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此商品
SAB5700378SAB4504439SAB1305912
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

-

species reactivity

rat, human, mouse

species reactivity

mouse, human

species reactivity

rat, human, mouse

species reactivity

human

Gene Information

human ... CHUK(1147), IKBKB(3551)

Gene Information

human ... CHUK(1147)

Gene Information

human ... CHUK(1147)

Gene Information

human ... CHUK(1147)

technique(s)

ELISA: 1:1000, western blot: 1:500-1:1000, immunohistochemistry: 1:50-1:100

technique(s)

western blot: 1:500-1:2000

technique(s)

ELISA: 1:5000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

technique(s)

western blot: 1:1000

一般描述

CHUK (conserved helix-loop-helix ubiquitous kinase) is located on human chromosome 10q24. IKK1/IKK-α has three ordered protein domains, namely, a kinase domain (KD), a ubiquitin-like domain (ULD) and a scaffold dimerization domain (SDD). IKKB (inhibitor of nuclear factor κ B kinase subunit β) is mapped to human chromosome 8p11. IKBKB codes for IκB kinase 2 (IKK2/IKKβ). IKK1 and IKK2 has a canonical MAP kinase kinase (MAPKK) activation loop motif.

免疫原

The antiserum was produced against synthesized peptide derived from human IKK-alpha around the phosphorylation site of Ser177.

Immunogen Range: 151-200

生化/生理作用

IKK1/IKKα (I-κ-B kinase 1) modulates nuclear factor κ-B (NF-κB) signaling, that is required for lymphoid organogenesis and adaptive immunity. IκB kinase α (IKKα) plays a major role in human skin cancer. This gene also controls terminal differentiation and multiplication of keratinocytes. IKKβ acts as the master regulator of cell survival and the inflammatory response.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Chapter 252 - NFκB: A Key Integrator of Cell Signaling
Handbook of Cell Signaling, 2069-2076 (2009)
I?B kinase α functions as a tumor suppressor in epithelial-derived tumors through an NF-κB-independent pathway.
Xie Y, et al.
Oncology Reports, 34(5), 2225-2232 (2015)
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Reid M A, et al.
Genes & Development, 30(16), 1837?1851-1837?1851 (2016)
A suite of novel human spermatozoal RNAs.
Ostermeier G C, et al.
Journal of Andrology, 26(1), 70-74 (2005)
Structural Basis for the Activation of IKK1/α.
Polley S, et al.
Cell Reports, 17(8), 1907-1914 (2016)

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