Merck

SAB4700115

Sigma-Aldrich

Monoclonal Anti-CD20-APC antibody produced in mouse

clone 2H7, purified immunoglobulin, buffered aqueous solution

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别名:
Anti-MS4A1
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

(Conjugation - APC)

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

2H7, monoclonal

形式

buffered aqueous solution

种属反应性

human, nonhuman primates

技术

flow cytometry: suitable using human blood cells using 10 μL reagent/100 μL of sample

同位素/亚型

IgG2a

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

2-8°C

靶向翻译后修饰

unmodified

基因信息

human ... MS4A1(931)

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SAB4701138SAB4700123SAB4700141
biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

Gene Information

human ... MS4A1(931)

Gene Information

human ... MRC1(4360)

Gene Information

human ... CD22(933)

Gene Information

human ... CD80(941)

species reactivity

human, nonhuman primates

species reactivity

-

species reactivity

human

species reactivity

human

conjugate

(Conjugation - APC)

conjugate

Allophycocyanin conjugate

conjugate

Allophycocyanin conjugate

conjugate

Allophycocyanin conjugate

一般描述

CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. It is associated with lipid rafts, but the intesity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR amd CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment.

特异性

The antibody 2H7 reacts with CD20 (Bp35), a 33-37 kDa non-glycosylated membrane receptor with four transmembrane domains, expressed on B lymphocytes (it is lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes.

免疫原

Human tonsillar B cells

应用

The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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