Merck

SAB4700284

Sigma-Aldrich

Monoclonal Anti-CD15 antibody produced in mouse

clone MEM-158, purified immunoglobulin, buffered aqueous solution

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别名:
Anti-FUT4, Anti-Lewis x Blood Group antigen
NACRES:
NA.41

生物来源

mouse

偶联物

unconjugated

抗体形式

purified immunoglobulin

antibody product type

primary antibodies

克隆

MEM-158, monoclonal

形式

buffered aqueous solution

species reactivity

human

浓度

1 mg/mL

technique(s)

flow cytometry: suitable

同位素/亚型

IgM

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

2-8°C

target post-translational modification

unmodified

Gene Information

human ... FUT4(2526)

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此商品
SAB4700789SAB4700924SAB4700005
species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

clone

MEM-158, monoclonal

clone

MMA, monoclonal

clone

BNI3, monoclonal

clone

LT95, monoclonal

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

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一般描述

Cluster of differentiation 15 (CD15), also known as fucosyltransferase 4 (FUT4)/ Lewis x blood group antigen, is encoded by the gene mapped to long arm of human chromosome 11q21. It is ubiquitously expressed in various tissues such as gastrointestinal tract, brain and leukocytes.
The antibody MEM-158 reacts with CD15, a cell membrane molecule 3-fucosyl-N-acetyllactosamine (3-FAL) strongly expressed on granulocytes, monocytes, macrophages, mast cells; it is also present on Langerhans cells and some myeloid precursors cells.

免疫原

Human granulocytes

应用

The reagent is designed for Flow Cytometry analysis using 10 μL reagent / 100 μL of sample.

生化/生理作用

Cluster of differentiation 15 (CD15)/fucosyltransferase 4 catalyzes the synthesis of Lex on the surface of the proliferating cells, in organ buds progressing in mesenchyma, during human embryogenesis. Overexpression of the gene has been associated with development of various type of cancers such as colon cancer, pancreatic cancer, gastric cancer and lung adenocarcinoma. siRNAs of FUT1/4 can be used as a potent therapeutic agent in human LeY-expressing cancers.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Sakiko Masuda et al.
The American journal of pathology, 189(4), 839-846 (2019-01-25)
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by the production of ANCAs and systemic necrotizing vasculitis in small vessels. Disordered regulation of neutrophil extracellular traps (NETs) is critically involved in the pathogenesis of AAV. NETs are web-like DNA decorated
The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21.
Reguigne I
Cytogenetics and Cell Genetics, 66, 104-106 (1994)
Li-Ning Jiang et al.
Asian journal of andrology (2018-09-11)
Lycopene is a natural compound that alleviates oxidative stress and inflammation, exerting therapeutic effects in a number of cancers. The aim of this study is to investigate the efficacy of lycopene in inhibiting prostate cancer. Cell viability assays indicated the
Filippo Veglia et al.
Nature, 569(7754), 73-78 (2019-04-19)
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that are crucial for the regulation of immune responses in cancer. These cells contribute to the failure of cancer therapies and are associated with poor clinical outcomes. Despite recent advances in
David Weisenburger-Lile et al.
Neurology(R) neuroimmunology & neuroinflammation, 6(4), e571-e571 (2019-07-30)
To better understand the functional state of circulating neutrophils in patients with ischemic stroke (IS) for planning future clinical trials. We analyzed by flow cytometry activation state of circulating neutrophils and the distribution of neutrophil peripheral subsets in 41 patients

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