Merck

SAB4700480

Sigma-Aldrich

Monoclonal Anti-CD45-FITC antibody produced in mouse

clone MEM-28, purified immunoglobulin, buffered aqueous solution

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别名:
Anti-LCA, Anti-PTPRC

生物来源

mouse

质量水平

偶联物

FITC conjugate

抗体形式

purified immunoglobulin

antibody product type

primary antibodies

克隆

MEM-28, monoclonal

形式

buffered aqueous solution

species reactivity

human

technique(s)

flow cytometry: suitable

同位素/亚型

IgG1

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

2-8°C

target post-translational modification

unmodified

Gene Information

human ... PTPRC(5788)

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此商品
SAB4700482SAB4700471SAB4700481
conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

unconjugated

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

MEM-28, monoclonal

clone

MEM-55, monoclonal

clone

MEM-28, monoclonal

clone

MEM-56, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

human

species reactivity

nonhuman primates, human

species reactivity

human

species reactivity

human

一般描述

The antibody MEM-28 reacts with all alternative forms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets.
The cluster of differentiation 45 (CD45) gene is mapped to human chromosome 1q31.3-q32.1. It codes for a type I transmembrane protein and is expressed in nucleated hematopoietic cells along within its precursors. The protein consists of a varying extracellular domain and a highly conserved intracellular domain.

免疫原

Human thymocytes and T lymphocytes

应用

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

生化/生理作用

Cluster of differentiation 45 (CD45) functions as a prototypic receptor and exhibits phosphatase activity. CD45 is implicated in the regulation of T-cell mediated B cell antigen receptor (BCR)-signaling. The encoded protein plays an essential role in antigen-stimulated proliferation of T lymphocytes and in thymic development. CD45 negatively regulates cytokine receptor signaling via suppressing JAK (Janus kinase) activity.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable


Certificates of Analysis (COA)

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CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
Irie-Sasaki J
Nature, 409, 349-354 (2001)
The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state.
Puck A
European Journal of Immunology, 47, 193-205 (2017)
Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.
Taher TE
Clinical Reviews in Allergy & Immunology, 53, 237-264 (2017)
T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity.
Szodoray P
The Journal of Allergy and Clinical Immunology, 138, 839-851 (2016)
I S Trowbridge et al.
Annual review of immunology, 12, 85-116 (1994-01-01)
CD45 is one of the most abundant leukocyte cell surface glycoproteins and is expressed exclusively upon cells of the hematopoietic system. Different isoforms of CD45 are generated by alternative splicing and are expressed in cell type-specific patterns on functional subpopulations

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