Merck

SAB4700520

Sigma-Aldrich

Monoclonal Anti-CD71 antibody produced in mouse

clone MEM-189, purified immunoglobulin, buffered aqueous solution

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别名:
Anti-TFRC, Anti-Transferrin Receptor
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

purified immunoglobulin

antibody product type

primary antibodies

克隆

MEM-189, monoclonal

形式

buffered aqueous solution

species reactivity

human

浓度

1 mg/mL

technique(s)

flow cytometry: suitable

同位素/亚型

IgG1

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

2-8°C

target post-translational modification

unmodified

Gene Information

human ... TFRC(7037)

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此商品
SAB4700515WH0000924M4SAB5201968
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

MEM-189, monoclonal

clone

MEM-75, monoclonal

clone

1B8, monoclonal

clone

6D9, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

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一般描述

Cluster of differentiation 71 (CD71), also known as transferrin receptor, is encoded by the gene mapped to human chromosome 3q29. CD71 is present on cells with high proliferation.
The antibody MEM-189 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes.

免疫原

KG1 human acute myelogenous leukaemia cell line

应用

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化/生理作用

Cluster of differentiation 71 (CD71) functions as an iron regulatory protein. Overexpression of the gene has been associated with the development of various types of cancers, including cholangiocarcinoma (CCA). Thus, CD71 protein is considered as a potential therapeutic target for CCA and iron overload. The encoded protein facilitates mitochondrial respiration and reactive oxygen species (ROS) production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is essential for their tumorigenic growth. Thus, aberrant expression of CD71 might also lead to the development of pancreatic cancer.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool
Jamnongkan W
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39 (2017)
Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation.
Jeong SM
Biochemical and Biophysical Research Communications, 471, 373-379 (2016)
Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen
Habashy HO
Breast Cancer Research and Treatment, 119, 283-293 (2010)
NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors.
Kashuba VI
Febs Letters, 419, 181-185 (1997)

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