Merck

SAB5700635

Sigma-Aldrich

Anti-Cyclin D1 antibody produced in rabbit

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别名:
BCL1, CCND1, Cyclin D1, D11S287E, PRAD1, U21B31, cyclin D1

生物来源

rabbit

质量水平

抗体形式

affinity isolated antibody

antibody product type

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

33

species reactivity

rat, human

浓度

0.74 mg/ml

technique(s)

immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

UniProt登记号

运输

wet ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... CCND1(595)

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此商品
SAB5700414SAB5701174ABE52
Anti-Cyclin D Antibody from rabbit, purified by affinity chromatography

Sigma-Aldrich

ABE52

Anti-Cyclin D Antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

-

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

monoclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

liquid

form

-

mol wt

33

mol wt

33

mol wt

-

mol wt

-

species reactivity

rat, human

species reactivity

rat, human

species reactivity

mouse, human, rat

species reactivity

human, mouse

一般描述

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 96-295 of human Cyclin D1 (NP_444284.1).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable


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