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Merck

SCP0038

Sigma-Aldrich

β 淀粉样蛋白 1-42 大鼠

≥90% (HPLC)

别名:

β-Amyloid 1-42, Amyloid for Rat, Rat Amyloid β 1-42

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About This Item

经验公式(希尔记法):
C199H307N53O59S1
分子量:
4417.95
分類程式碼代碼:
12352200
NACRES:
NA.32

化驗

≥90% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥75%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

一般說明

淀粉样蛋白 β (Aβ) 1-42 是在阿尔茨海默病(AD)中出现的淀粉样斑块的主要成分。它具有交叉的β结构和平行的β片层

應用

大鼠淀粉样蛋白 β 1-42已被用作脑室内(ICV)注射/海马内灌注的淀粉样蛋白β (Aβ)寡聚糖,用于建立大鼠阿尔茨海默病(AD)模型。

生化/生理作用

与Aβ(1–40)相比,淀粉样蛋白 β 1-42更容易在体外形成淀粉样纤维丝。Aβ1-42注射液可导致脑功能失调,出现学习和记忆缺损。淀粉样蛋白β(Aβ)是指衍生自淀粉样前体蛋白的肽,其长度在37–43个氨基酸之间变化。Aβ(s)肽,其肽片段和突变片段用于研究广泛的代谢和调节功能,包括激酶的激活、胆固醇转运的调节、作为转录因子的功能和炎症的调节因子。Aβ(s)肽及其肽片段还用于研究氧化应激、金属结合和蛋白质交联机制,例如阿尔茨海默病和神经变性。

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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