SML0304

Sigma-Aldrich

Caged MK801

≥98% (HPLC)

别名:
Dizocilpine N-(4,5-dimethoxy-2-nitrobenzyl) carbamate, 10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine-12-carboxylic acid (4,5-dimethoxy-2-nitrophenyl)methyl ester, cMK801
Empirical Formula (Hill Notation):
C26H24N2O6
CAS号:
分子量:
460.48
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to light yellow

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

COc1cc(COC(=O)N2[C@@H]3Cc4ccccc4[C@@]2(C)c5ccccc35)c(cc1OC)[N+]([O-])=O

InChI

1S/C26H24N2O6/c1-26-19-10-6-4-8-16(19)12-22(18-9-5-7-11-20(18)26)27(26)25(29)34-15-17-13-23(32-2)24(33-3)14-21(17)28(30)31/h4-11,13-14,22H,12,15H2,1-3H3/t22-,26+/m1/s1

InChI key

WZDXUEMCALAOAY-GJZUVCINSA-N

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Caged MK801 is an inactive caged form of the potent selective non-competitive irreversible NMDA glutamate receptor open-channel blocker MK801. Caged MK801 is cleaved by exposure to UV light, liberating the active MK801. The caged compound is stable within cells. Intracellular compartment-specific photorelease allowed study the locus of induction and expression of timing-dependent long-term depression (t-LTD). Caged MK801 is thus a useful tool to uncover compartment-specific biological functions.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

RIDADR

NONH for all modes of transport

WGK Germany

3

Xiangping Peng et al.
International journal of molecular medicine, 44(1), 227-239 (2019-05-23)
Endoplasmic reticulum (ER) stress in alveolar epithelial cells (AECs) is associated with the pathogenesis of pulmonary fibrosis. Bone marrow‑derived mesenchymal stromal cells (BM‑MSCs) can exert protective effects on ER‑stressed AECs via paracrine signaling. In the present study, mouse lung epithelial...
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