Merck
所有图片(1)

文件

SML0435

Sigma-Aldrich

AF-DX 116

≥98% (HPLC)

所有图片(1)
别名:
11-[[2-[（二乙胺基）甲基]-1-哌啶基]乙酰基]-5,1 1-二氢-6-吡啶并[2,3-b][1,4]苯二氮卓-6-酮, Otenzepad
Empirical Formula (Hill Notation):
C24H31N5O2
CAS号:
102394-31-0
分子量:
421.54
MDL编号:
MFCD00864743
PubChem化学物质编号:
329824718
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

颜色

white to beige

溶解性

DMSO: 5 mg/mL (clear solution; warmed)

储存温度

room temp

SMILES string

CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24

InChI

1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)

InChI key

UBRKDAVQCKZSPO-UHFFFAOYSA-N

比较类似商品

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此商品
SML0620SML2568SML1382
AF-DX 116 ≥98% (HPLC)

Sigma-Aldrich

SML0435

AF-DX 116

Sigma-Aldrich

Sigma-Aldrich

SML0620

AF-DX 384 Free Base

XMD8-87 ≥98% (HPLC)

Sigma-Aldrich

SML2568

XMD8-87

XMD8-92 ≥98% (HPLC)

Sigma-Aldrich

SML1382

XMD8-92

form

powder

form

powder

form

powder

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

-

drug control

-

drug control

-

color

white to beige

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution; warmed)

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 25 mg/mL, clear

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

应用

AF-DX 116 用作 M2 毒蕈碱受体（M2AChR）选择性拮抗剂，以研究 M2AChR 对年轻糖尿病大鼠齿状回基底和碳水化合物刺激长期增强（DG-LTP）的调节和海马细胞前神经生长因子（proNGF）分泌的影响。

生化/生理作用

AF-DX 116 可在反复冷应激诱导的低血压大鼠模型中升高血压和心率。因此，它可以治疗与迷走神经症型自主神经功能障碍相关的低血压。
AF-DX 116是一种选择性M2毒蕈碱乙酰胆碱受体拮抗剂。

特点和优势

该化合物在受体分类和信号转导手册的 乙酰胆碱受体（毒蕈碱） 页面上有详细描述。想要浏览手册的其他页面， 请单击此处。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificates of Analysis (COA)

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示例

T1503
货号
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25G
包装规格/数量

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其他客户在看

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Carbachol European Pharmacopoeia (EP) Reference Standard

Y0000113

卡巴胆碱

M Marti et al.
Journal of veterinary pharmacology and therapeutics, 28(6), 565-574 (2005-12-14)
The goal of this study was to investigate the effect of bethanechol (BeCh) on contractility patterns of smooth muscle preparations of equine duodenum descendens, jejunum, caecum and pelvic flexure in vitro. Concentration-response relationships were developed for BeCh using in vitro
Eugeny E Nikolsky et al.
The Journal of physiology, 560(Pt 1), 77-88 (2004-07-16)
The effects of cholinergic drugs on the quantal contents of the nerve-evoked endplate currents (EPCs) and the parameters of the time course of quantal release (minimal synaptic latency, main modal value of latency histogram and variability of synaptic latencies) were
S Gigout et al.
Neuroscience, 223, 399-411 (2012-08-07)
Acetylcholine has been implicated in higher cortical functions such as learning, memory and cognition, yet the cellular effects of muscarinic acetylcholine receptor (mAChR) activation are poorly understood in the human cortex. Here we investigated the effect of the mAChR agonist
Jun Nomura et al.
Life sciences, 72(18-19), 2121-2126 (2003-03-12)
The existence and functions of muscarinic acetylcholine (mACh) receptors in human T lymphocytes were investigated. RT-PCR analysis demonstrated the presence of M(1) and M(2) subtypes of mACh receptors in human T lymphocytes. Pretreatment with oxotremorine-M (Oxo-M) caused the increase in
Makoto Ukai et al.
European journal of pharmacology, 492(2-3), 183-187 (2004-06-05)
The effects of anticholinergic drugs selective for muscarinic receptor subtypes on prepulse inhibition of acoustic startle response were determined in mice. The prepulse inhibition is associated with sensorimotor information processing in the brain. The anticholinergic agent scopolamine (0.3 mg/kg, s.c.)
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