SML0584

Sigma-Aldrich

NNGH

≥98% (HPLC)

别名:
BML-205, N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
Empirical Formula (Hill Notation):
C13H20N2O5S
CAS号:
分子量:
316.37
MDL编号:
PubChem化学物质编号:

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 15 mg/mL, clear

储存温度

2-8°C

SMILES string

COc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO

InChI

1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16)

InChI key

JIRXORZYIXSWOB-UHFFFAOYSA-N

包装

5, 25 mg in glass bottle

生化/生理作用

NNGH is a potent and cell-permeable inhibitor of matrix metalloproteinase 3 (MMP-3,stromelysin 1, progelatinase). NNGH has been used to inhibit MMP-3 in a variety of studies. Inhibition of MMP-3 with NNGH significantly suppressed the expression of iNOS and pro-inflammatory cytokines and the activities of NF-KB, AP-1, and MAPK in LPS-stimulated microglia, suggesting a role for MMP-3 in neuroinflammation.

特点和优势

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

法律信息

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Sung Yong Eum et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(11), G992-G1001 (2014-04-20)
The intestinal epithelium forms a selective barrier maintained by tight junctions (TJs) and separating the luminal environment from the submucosal tissues. N-acylhomoserine lactone (AHL) quorum-sensing molecules produced by gram-negative bacteria in the gut can influence homeostasis of the host intestinal...
Anthony Martin et al.
Journal of cellular physiology, 232(12), 3798-3807 (2017-02-19)
We have recently demonstrated that RUNX2 promoted, and 17β-Estradiol (E2) diminished, association of RANKL with the cell membrane in pre-osteoblast cultures. Here we show that, similar to E2, dihydrotestosterone (DHT) diminishes association of RANKL, and transiently transfected GFP-RANKL with the...
Sandra Rother et al.
Acta biomaterialia, 45, 143-154 (2016-10-19)
An imbalance between tissue-degrading matrix metalloproteinases (MMPs) and their counterparts' tissue inhibitors of metalloproteinases (TIMPs) causes pathologic extracellular matrix (ECM) degradation in chronic wounds and requires new adaptive biomaterials that interact with these regulators to re-establish their balance. Sulfated glycosaminoglycans...
Evy Lefevere et al.
Glia, 68(12), 2643-2660 (2020-07-10)
Increasing evidence suggests that functional impairments at the level of the neurovascular unit (NVU) underlie many neurodegenerative and neuroinflammatory diseases. While being part of the NVU, astrocytes have been largely overlooked in this context and only recently, tightening of the...
Tu Hu et al.
Current eye research, 45(5), 591-603 (2019-10-31)
Purpose: Evidences suggest that during ischemia/reperfusion events, neuronal loss in ganglion cell layers (GCLs) occurs initially in the peripheral retinae followed by the central. However, which key molecule or factor mediates this selective loss needs elucidation. In the present study...

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