Merck
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SML0601

Sigma-Aldrich

BPTES

≥95% (HPLC)

Synonym(s):
双-2-(5-苯基乙酰胺基-1,3,4-噻二唑-2-基)乙基硫醚
Empirical Formula (Hill Notation):
C24H24N6O2S3
CAS Number:
Molecular Weight:
524.68
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

100

测定

≥95% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES string

O=C(CC1=CC=CC=C1)NC2=NN=C(S2)CCSCCC3=NN=C(NC(CC4=CC=CC=C4)=O)S3

InChI

1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32)

InChI key

MDJIPXYRSZHCFS-UHFFFAOYSA-N

应用

双-2-(5-苯基乙酰胺基-1,3,4-噻二唑-2-基)乙基硫醚(BPTES)已被用作谷氨酰胺酶抑制剂。

包装

5, 25 mg in glass bottle

生化/生理作用

BPTES是谷氨酰胺酶GLS1(KGA)的选择性抑制剂,GLS1存在于肾和脑中,由myc正向调节,在许多肿瘤和肿瘤细胞系中高度表达。谷氨酰胺酶可将谷氨酰胺转化为谷氨酸,谷氨酸是脑中重要的兴奋性神经递质,可进一步氧化成α-酮戊二酸(供给三羧酸(TCA)循环)和谷胱甘肽,谷胱甘肽对控制活性氧(ROS)水平很重要,对癌细胞生长尤为重要。BPTES可减缓胶质瘤细胞的生长。BPTES是一种非竞争性抑制剂,Ki为3 μmM。
牛痘病毒(VACV)需要谷氨酰胺代谢才能实现最佳复制。双-2-(5-苯基乙酰胺基-1,3,4-噻二唑-2-基)乙基硫醚(BPTES)抑制谷氨酰胺分解可能有望治疗痘病毒感染。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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