Merck

SML0607

Sigma-Aldrich

Ceranib-2

≥98% (HPLC)

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别名:
3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone, 3-[3-(4-Methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone
经验公式(希尔记法):
C25H19NO3
分子量:
381.42

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

运输

wet ice

储存温度

−20°C

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1 of 4

此商品
SML2689SML1085L2545
Sigma-Aldrich

SML0607

Ceranib-2

EN6 ≥98% (HPLC)

SML2689

EN6

Retro-2 ≥98% (HPLC)

SML1085

Retro-2

LY225910 ≥98% (HPLC)

L2545

LY225910

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

DMSO: >20 mg/mL

color

white to beige

color

white to beige

color

white to beige

color

off-white

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

生化/生理作用

Ceranib-2 is a nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and inhibits cell proliferation.

储存分类代码

11 - Combustible Solids

WGK

WGK 3


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Violeta Heras et al.
Cell metabolism, 32(6), 951-966 (2020-10-21)
Childhood obesity, especially in girls, is frequently bound to earlier puberty, which is linked to higher disease burden later in life. The mechanisms underlying this association remain elusive. Here we show that brain ceramides participate in the control of female
Gang Pei et al.
The EMBO journal, 40(13), e106272-e106272 (2021-05-05)
Cellular stress has been associated with inflammation, yet precise underlying mechanisms remain elusive. In this study, various unrelated stress inducers were employed to screen for sensors linking altered cellular homeostasis and inflammation. We identified the intracellular pattern recognition receptors NOD1/2

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