SML0750

Sigma-Aldrich

TPPU

≥98% (HPLC)

别名:
1-三氟甲氧基苯基-3-(1-丙酰哌啶-4-基)脲, N-[1-(1-氧丙基)-4-哌啶基]-N′-[4-(三氟甲氧基)苯基]-脲
Empirical Formula (Hill Notation):
C16H20F3N3O3
CAS号:
分子量:
359.34

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear (warmed)

storage temp.

2-8°C

Application

TPPU已被用作可溶性环氧化物水解酶(SEH)抑制剂,用于表征其在啮齿动物中的药代动力学(PK)和药效学特性。它还被用作SEH抑制剂,用于研究其对神经组织中12,13-二羟基-9Z-十八烯酸(12,13-DiHOME)浓度的影响。

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

TPPU 是一种强效 sEH 抑制剂 (IC 50 = 3.7 nM),已证明其在食蟹猴中具有非常有利的 PK 属性。sEH 可将环氧二十碳三烯酸 (EET) 转化为二羟基月桂三烯酸 (DHET),sEH 抑制剂显示抗炎和抗动脉粥样硬化作用。

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

分析证书
原产地证书 (CofO)
Annika I Ostermann et al.
Prostaglandins & other lipid mediators, 121(Pt A), 131-137 (2015-06-29)
Epoxides from polyunsaturated fatty acids (PUFAs) are potent lipid mediators. In vivo stabilization of these epoxides by blockade of the soluble epoxide hydrolase (sEH) leads to anti-inflammatory, analgesic and normotensive effects. Therefore, sEH inhibitors (sEHi) are a promising new class...
The oxidized linoleic acid metabolite 12, 13-DiHOME mediates thermal hyperalgesia during inflammatory pain
Zimmer B, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863(7), 669-678 (2018)
Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy) phenyl] urea (TPPU): Resulting drug levels and modulation of oxylipin pattern
Ostermann A I, et al.
Prostaglandins & other lipid mediators, 121 (2015)
Béla Zimmer et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1863(7), 669-678 (2018-04-07)
Eicosanoids play a crucial role in inflammatory pain. However, there is very little knowledge about the contribution of oxidized linoleic acid metabolites in inflammatory pain and peripheral sensitization. Here, we identify 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME), a cytochrome P450-derived linoleic acid metabolite...
Wenjun Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(42), 8188-8203 (2020-09-26)
Alzheimer's disease (AD) is the leading cause of late-onset dementia, and there exists an unmet medical need for effective treatments for AD. The accumulation of neurotoxic amyloid-β (Aβ) plaques contributes to the pathophysiology of AD. EPHX2 encoding soluble epoxide hydrolase...

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