Annika I Ostermann et al.
Prostaglandins & other lipid mediators, 121(Pt A), 131-137 (2015-06-29)
Epoxides from polyunsaturated fatty acids (PUFAs) are potent lipid mediators. In vivo stabilization of these epoxides by blockade of the soluble epoxide hydrolase (sEH) leads to anti-inflammatory, analgesic and normotensive effects. Therefore, sEH inhibitors (sEHi) are a promising new class...
The oxidized linoleic acid metabolite 12, 13-DiHOME mediates thermal hyperalgesia during inflammatory pain
Zimmer B, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863(7), 669-678 (2018)
Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy) phenyl] urea (TPPU): Resulting drug levels and modulation of oxylipin pattern
Ostermann A I, et al.
Prostaglandins & other lipid mediators, 121 (2015)
Béla Zimmer et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1863(7), 669-678 (2018-04-07)
Eicosanoids play a crucial role in inflammatory pain. However, there is very little knowledge about the contribution of oxidized linoleic acid metabolites in inflammatory pain and peripheral sensitization. Here, we identify 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME), a cytochrome P450-derived linoleic acid metabolite...
Wenjun Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(42), 8188-8203 (2020-09-26)
Alzheimer's disease (AD) is the leading cause of late-onset dementia, and there exists an unmet medical need for effective treatments for AD. The accumulation of neurotoxic amyloid-β (Aβ) plaques contributes to the pathophysiology of AD. EPHX2 encoding soluble epoxide hydrolase...