Merck
  • SML0788
All Photos(2)

SML0788

Sigma-Aldrich

A 83-01

≥98% (HPLC)

All Photos(2)
Synonym(s):
3-（6-甲基-2-吡啶基）-N-苯基-4-（4-喹啉基）-1H-吡唑-1-硫代甲酰胺, A-83-01, A83-01
Empirical Formula (Hill Notation):
C25H19N5S
CAS Number:
909910-43-6
Molecular Weight:
421.52
NACRES:
NA.77

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质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

−20°C

应用

A 83-01已被用作转化生长因子β激酶1型受体的抑制剂。

包装

5, 25 mg in glass bottle

生化/生理作用

A 83-01是一种TGFβ激酶/激活素受体样激酶（ALK 5）的抑制剂（IC50= 12nM），可阻止Smad2/3的磷酸化并抑制TGFβ诱导的生长。 A 83-01可阻断Smad2的磷酸化并抑制TGF-β诱导的上皮-间质转化。 此外，A 83-01可抑制由TGFβI型受体ALK-5、活化素IB型受体ALK-4、和结节型I受体ALK-7诱导的转录活性。 A-83-01可诱导新生Nkx2.5-eGFP（+）细胞的扩增。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

Certificate of Analysis

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Certificate of Origin

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