SML0920

Sigma-Aldrich

α-Phenyl tropolone

≥98% (HPLC)

别名:
2-Hydroxy-3-phenyl-2,4,6-cycloheptatrien-1-one, 3-Phenyltropolone
Empirical Formula (Hill Notation):
C13H10O2
CAS号:
分子量:
198.22
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

, yellow to gray to brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

α-Phenyl tropolone is a very potent inhibitor of the hisotne deacetylases HDAC2 and HDAC8 (Ki = 0.26 and 1.09 nM, respectively). The compound, α-Phenyl tropolone, does not affect other HDAC isoforms up to concentrations of 20 μM, with the exception of HDAC 6 (Ki = 527 nM).

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Precautionary Statements

RIDADR

UN 3077 9 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

分析证书
原产地证书 (CofO)
S V Demyanenko et al.
Brain research bulletin, 162, 151-165 (2020-06-28)
Epigenetic processes play important roles in brain responses to ischemic injury. We studied effects of photothrombotic stroke (PTS, a model of ischemic stroke) on the intracellular level and cellular localization of histone deacetylases HDAC3, HDAC4 and HDAC6 in the rat...
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