Merck

SML1085

Sigma-Aldrich

Retro-2

≥98% (HPLC)

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别名:
2,3-二氢-2-(5-甲基-2-噻吩基)-3-苯基-4(1H)-喹唑啉酮
Empirical Formula (Hill Notation):
C19H16N2OS
分子量:
320.41
MDL编号:
PubChem化学物质编号:

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES string

O=C1C2=CC=CC=C2NC(C3=CC=C(C)S3)N1C4=CC=CC=C4

InChI

1S/C19H16N2OS/c1-13-11-12-17(23-13)18-20-16-10-6-5-9-15(16)19(22)21(18)14-7-3-2-4-8-14/h2-12,18,20H,1H3

InChI key

BOAPXDSRULBILC-UHFFFAOYSA-N

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此商品
SML1184SML0140L2545
Retro-2 ≥98% (HPLC)

Sigma-Aldrich

SML1085

Retro-2

OF-1 ≥98% (HPLC)

Sigma-Aldrich

SML1184

OF-1

BV02 ≥98% (HPLC)

Sigma-Aldrich

SML0140

BV02

LY225910 ≥98% (HPLC)

Sigma-Aldrich

L2545

LY225910

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

white to off-white

color

off-white

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: >5 mg/mL

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

应用

Retro-2已被用于估算志贺毒素亚基B (STxB)-Cy3的逆向转运。

生化/生理作用

Retro-2是从内体向高尔基体逆行转运的无毒抑制剂,可选择性保护细胞免受蓖麻毒素、霍乱毒素和志贺氏样毒素的上海,而不会影响细胞区室形态、内源性逆行转运或其他转运步骤。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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示例

T1503
货号
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25G
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Zhouguang Jiao et al.
Journal of applied toxicology : JAT, 40(10), 1440-1450 (2020-06-01)
The current study explores the detoxification effect of Retro-2 on ricin toxin (RT) cytotoxicity, as well as the mechanisms underlying such effects, to provide a basis for follow-up clinical applications of Retro-2. The mouse-derived mononuclear/macrophage cell line, RAW264.7, was used
Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.
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Journal of virology, 94(24) (2020-10-09)
Herpes simplex virus 1 (HSV-1) causes significant morbidity and mortality in humans worldwide. HSV-1 enters epithelial cells via an endocytosis mechanism that is low-pH dependent. However, the precise intracellular pathway has not been identified, including the compartment where fusion occurs.
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The parasitophorous vacuoles (PVs) that insulate Leishmania spp. in host macrophages are vacuolar compartments wherein promastigote forms differentiate into amastigote that are the replicative form of the parasite and are also more resistant to host responses. We revisited the biogenesis

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