Merck

SML1229

Sigma-Aldrich

2′,3′-cGAMP 钠盐

≥98% (HPLC)

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别名:
2′,5′-3′,5′-cGAMP, cGAMP(2′-5′), c[G(2′,5′)pA(3′,5′)p] 钠盐, 环化[G(2′,5′)pA(3′,5′)p]
Empirical Formula (Hill Notation):
C20H24N10O13P2 · xNa+
分子量:
674.41 (free acid basis)
PubChem化学物质编号:
NACRES:
NA.77

描述

contains 0.5μmol of powder (approx. 0.335mg)

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

储存温度

−20°C

SMILES string

O=C1N=C(N)NC2=C1N=CN2[C@H](O3)[C@H](OP(OC[C@@H]4[C@@H](O5)[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O4)(O)=O)[C@H](O)[C@H]3COP5(O)=O

InChI

1S/C20H24N10O13P2/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1

InChI key

XRILCFTWUCUKJR-INFSMZHSSA-N

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此商品
319856SML1957A2846
2′,3′-cGAMP sodium salt ≥98% (HPLC)

Sigma-Aldrich

SML1229

2′,3′-cGAMP 钠盐

ML RR-S2 CDA sodium salt ≥95% (HPLC)

Sigma-Aldrich

SML1957

ML RR-S2 CDA 钠盐

form

powder

form

-

form

powder

form

solid

color

white to beige

color

-

color

white to beige

color

off-white to light tan

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

-

description

contains 0.5μmol of powder (approx. 0.335mg)

description

-

description

-

description

-

应用

2′,3′-cGAMP钠盐被用来鉴定能够和人干扰素基因(STING)激活剂结合的小分子。它还被用来研究I型干扰素胞浆DNA应答。

生化/生理作用

2′,3′-cGAMP (环化[G(2′,5′)pA(3′,5′)p]) 是STING(干扰素基因激活剂)途径的天然兴奋剂,被发现是抗病毒先天免疫途径。2′3′-cGAMP是在哺乳动物细胞中,由胞质DNA传感器(CGAMP合成酶)通过结合STING,启动干扰素应答,激活先天免疫途径,而产生的二级信使。 2′3′-cGAMP和人STING亲和性比和细菌 3′3′-环化二核苷酸(CDNs)要高得多,1Kd是4.59 nMSTING,相比之下,结合细菌3′3′-CDNs是>1 μM。

制备说明

2′,3′-cGAMP可溶于水和水性缓冲液(>> 5 mM, 没有确定溶解极限)。

相关产品

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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