Merck

SML2794

Sigma-Aldrich

Erastin2

≥98% (HPLC)

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别名:
2-((4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)methyl)-3-(4-isopropoxybiphenyl-3-yl)quinazolin-4(3H)-one, 2-[[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1′-biphenyl]-3-yl]-4(3H)-quinazolinone, 35MEW28
经验公式(希尔记法):
C36H35ClN4O4
分子量:
623.14

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O=C(N(C1=C(OC(C)C)C=CC(C2=CC=CC=C2)=C1)C(CN3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)=N5)C6=C5C=CC=C6

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此商品
329600SML0815SML1205
Erastin2 ≥98% (HPLC)

SML2794

Erastin2

Erastin A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.

329600

Erastin

YMU1 ≥98% (HPLC)

SML0815

YMU1

BVT.2733 ≥98% (HPLC)

SML1205

BVT.2733

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 50 mg/mL

solubility

DMSO: 1 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white

color

white to light brown

color

white to light brown

生化/生理作用

Erastin2 is an Erastin analog with greatly improved system xc- (SLC7A11/xCT + SLC3A2/4F2hc) inhibitory potency (Erastin2 IC50 = 3.5 nM/CCF-STTG1; Erastin IC50 = 200 nM/HT-1080, 140 nM/Calu-1; Glu release assay) and ferropotosis induction efficacy (HT-1080 EC50 = 150 nM/Erastin2 vs. 1.2 μM/Erastin).

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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