Merck

SML3435

Sigma-Aldrich

Momordin Ιc

≥98% (HPLC)

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别名:
(3β)-17-Carboxy-28-norolean-12-en-3-yl 3-O-β-D-xylopyranosyl-β-D-glucopyranosiduronic acid, Mormordin Ic
经验公式(希尔记法):
C41H64O13
CAS号:
分子量:
764.94

质量水平

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D 12 to 17° in methanol (c=0.5 g/100mL)

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

-10 to -25°C

InChI

1S/C41H64O13/c1-36(2)14-16-41(35(49)50)17-15-39(6)20(21(41)18-36)8-9-24-38(5)12-11-25(37(3,4)23(38)10-13-40(24,39)7)52-34-29(46)30(28(45)31(54-34)32(47)48)53-33-27(44)26(43)22(42)19-51-33/h8,21-31,33-34,42-46H,9-19H2,1-7H3,(H,47,48)(H,49,50)/t21-,22+,23-,24+,25-,26-,27+,28-,29+,30-,31-,33-,34+,38-,39+,40+,41-/m0/s1

InChI key

HWYBGIDROCYPOE-WEAQAMGWSA-N

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此商品
SMB00424SML3544SML3611
Sigma-Aldrich

SML3435

Momordin Ιc

桔梗皂苷D ≥98% (HPLC)

SMB00424

桔梗皂苷D

Sigma-Aldrich

SML3544

Ginsenoside Ro

Rubusoside ≥95% (HPLC)

SML3611

Rubusoside

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

-10 to -25°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

-

color

white to beige

color

white to beige

生化/生理作用

Potent inhibitor of SUMO-specific protease 1 (SENP1) that increases SUMOylated proteins in PC3 cells

目录

Momordin Ιc, a pentacyclic triterpenoid isolated from fruit of Kochia scoparia (L.) and other medical plants, is a potent inhibitor of SUMO-specific protease 1 (SENP1) that increases SUMOylated proteins in PC3 cells. Momordin Ιc inhibits cell proliferation and induced cell death in prostate cancer PC3 xenograft mouse model. Momordin Ιc decreases serum glucose and ethanol levels after oral administration through acceleration of gastrointestinal transit.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Small-Molecule Inhibitors Targeting Protein SUMOylation as Novel Anticancer Compounds
Yang Y, Xia Z, Wang X, Zhao X, Sheng Z, Ye Y, He G, Zhou L, Zhu H, Xu N, Liang S
Molecular Pharmacology (2018)
Y Li et al.
European journal of pharmacology, 392(1-2), 71-77 (2000-04-05)
Possible involvement of 5-hydroxytryptamine (5-HT), 5-HT receptors and prostaglandins in the acceleration of gastrointestinal transit by momordin Ic was investigated in mice. Accelerative effect of momordin Ic (25 mg/kg, p.o.) on gastrointestinal transit was attenuated by pretreatment with a bolus
Jingjing Wu et al.
Oncotarget, 7(37), 58995-59005 (2016-07-28)
SUMO-specific protease 1 (SENP1), a member of the de-SUMOylation protease family, is elevated in prostate cancer (PCa) cells and is involved in PCa pathogenesis. Momordin Ιc (Mc), a natural pentacyclic triterpenoid, inhibited SENP1 in vitro, as reflected by reduced SENP1C-induced

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