Merck

SRP0108

Sigma-Aldrich

HDAC-6 human

recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

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别名:
HD6, Histone deacetylase 6, JM21
NACRES:
NA.32

生物来源

human

重组

expressed in baculovirus infected insect cells

检测方案

≥80% (SDS-PAGE)

形式

aqueous solution

分子量

159 kDa

包装

pkg of 50 μg

NCBI登记号

UniProt登记号

运输

dry ice

储存温度

−70°C

Gene Information

human ... HDAC6(10013)

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HDAC-6 human recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

Sigma-Aldrich

SRP0108

HDAC-6 human

HDAC6 H611A human recombinant, expressed in baculovirus infected Sf9 cells, ≥79% (SDS-PAGE)

Sigma-Aldrich

SRP0311

HDAC6 H611A human

HDAC6 H216A human recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)

Sigma-Aldrich

SRP0310

HDAC6 H216A human

HDAC-8 human recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

Sigma-Aldrich

SRP0110

HDAC-8 human

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected insect cells

assay

≥80% (SDS-PAGE)

assay

≥79% (SDS-PAGE)

assay

≥75% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

form

aqueous solution

form

aqueous solution

form

aqueous solution

form

aqueous solution

mol wt

159 kDa

mol wt

161 kDa

mol wt

161 kDa

mol wt

42.4 kDa

NCBI accession no.

BC069243

NCBI accession no.

NM_006044

NCBI accession no.

NM_006044

NCBI accession no.

NM_018486

一般描述

HDAC6 (histone deacetylase 6) is a member of the HDAC family of enzyme which are generally linked with gene expression and chromatin dynamics. This protein resides exclusively in the cytoplasm and is present in the perinuclear punctate structures as well as the leading edges of the cell.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

生化/生理作用

HDAC6 (histone deacetylase 6) functions as a microtubule or tubulin deacetylase, which in turn regulates microtubule-dependent chemotactic cell motility. This protein shows colocalization with p150glued protein, a dynactin component. It contains a ubiquitin binding zinc finger, and interacts with ubiquitinated proteins post-proteasomal inhibition. It is essential for the survival of inflammatory breast cancers (IBCs), though does not function as an oncogene. Treatment of IBC cells with HDAC6 inhibitor ricolinostat (ACY1215) results in the inhibition of IBC cell proliferation both in vitro and in vivo.

单位定义

One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37°C.

外形

Formulated in 40 mM Tris-HCl pH8.0, 110mM NaCl, 2.2 mM KCl, 0.04% Tween20, 3mM DTT, and 20% glycerol.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress.
Kawaguchi Y et al
Cell, 115(6), 727-738 (2003)
Charlotte Hubbert et al.
Nature, 417(6887), 455-458 (2002-05-25)
Reversible acetylation of alpha-tubulin has been implicated in regulating microtubule stability and function. The distribution of acetylated alpha-tubulin is tightly controlled and stereotypic. Acetylated alpha-tubulin is most abundant in stable microtubules but is absent from dynamic cellular structures such as
HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers.
Putcha P
Breast Cancer Research, 17(1), 149-149 (2015)

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