Merck
  • SRP0120
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SRP0120

Sigma-Aldrich

Sirtuin 6 human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

Synonym(s):
NAD-dependent ADP-ribosyltransferase sirtuin-6, SIR2L6, SIRT6, sir2-like 6
NACRES:
NA.32

生物来源

human

重组

expressed in E. coli

检测方案

≥70% (SDS-PAGE)

形式

aqueous solution

分子量

65 kDa

包装

pkg of 100 μg

储存条件

avoid repeated freeze/thaw cycles

浓度

>0.02 mg/mL

NCBI登记号

UniProt登记号

运输

dry ice

储存温度

−70°C

Gene Information

human ... SIRT6(51548)

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Sirtuin 6 human recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

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Sirtuin 5 human recombinant, expressed in E. coli, ≥50% (SDS-PAGE)

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Sirtuin 5 human

Sirtuin 4 human recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

Sigma-Aldrich

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Sirtuin 4 human

biological source

human

biological source

human

biological source

human

biological source

human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥50% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

form

aqueous solution

form

aqueous solution

form

aqueous solution

form

aqueous solution

mol wt

65 kDa

mol wt

46 kDa

mol wt

59.8 kDa

mol wt

59 kDa

packaging

pkg of 100 μg

packaging

pkg of 100 μg

packaging

pkg of 100 μg

packaging

pkg of 100 μg

一般描述

Sirtuin 6 (Sir6) is encoded by the gene mapped to human chromosome 19p13.3, a region linked with development of acute leukemia. Sir 6 is mainly expressed in bone cells and in the ovaries, but it is absent in the bone marrow. Sirt6 is a chromatin-associated protein localized specifically in nucleus.
Human Sirtuin 6, GenBank Accession No. NM_016539), full length with N-terminal ST tag, MW = 65kDa, expressed in Escherichia coli expression system.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

生化/生理作用

Sirtuin 6 (Sir6) is a mono-ADP-ribosyltransferase, which catalyzes the transfer of ADP-ribose moiety from NAD to itself and histones. It has been implicated in the regulation of DNA repair, genomic stability and telomere integrity, gene expression, and metabolism. In addition, it also prevents age-related disorders and premature aging. Sir6 plays a vital role in the inhibition of nuclear factor-κB (NF-κB)–mediated inflammatory responses in rheumatoid joints. Hence, Sir6 is considered to be a potent target for treatment of rheumatoid arthritis (RA). Sir6 is also majorly implicated in the regulation of glucose and fat metabolism. Sir6 prevent cardiac hypertrophy in vitro via inhibiting NF-κB-dependent transcriptional activity and this effect is relied on its deacetylase activity.

外形

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 20% glycerol.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

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