Merck

SRP0309

Sigma-Aldrich

ATAT1 人

recombinant, expressed in E. coli, ≥55% (SDS-PAGE)

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别名:
TAT
NACRES:
NA.32

生物来源

human

重组

expressed in E. coli

检测方案

≥55% (SDS-PAGE)

形式

aqueous solution

分子量

52 kDa

包装

pkg of 50 μg

UniProt登记号

运输

dry ice

储存温度

−70°C

Gene Information

human ... ATAT1(79969)

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SAB2109036HPA050999HPA046816
ATAT1 human recombinant, expressed in E. coli, ≥55% (SDS-PAGE)

Sigma-Aldrich

SRP0309

ATAT1 人

recombinant

expressed in E. coli

recombinant

-

recombinant

-

recombinant

-

assay

≥55% (SDS-PAGE)

assay

-

assay

-

assay

-

form

aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

mol wt

52 kDa

mol wt

46 kDa

mol wt

-

mol wt

-

packaging

pkg of 50 μg

packaging

-

packaging

antibody small pack of 25 μL

packaging

antibody small pack of 25 μL

一般描述

Human α tubulin acetyltransferase 1, or ATAT1, (GenBank Accession No. NM_001031722 (var1)), amino acids 2 – 224 with N-terminal GST-tag, MW=52 kDa, expressed in an E. coli expression system.
The αTAT1 (α tubulin acetyltransferase 1) protein sequence of αTAT1 is highly conserved among eukaryotes. αTAT1 is a member of Gcn5 (general control non-depressible 5)-related N-acetyltransferase superfamily and is mostly present in ciliated organisms. It has also been identified in Tetrahymena, nematodes, zebrafish and mice.

生化/生理作用

ATAT1 (α tubulin acetyltransferase 1) catalyses the acetylation of lysine 40 of α-tubulin and microtubule. ATAT1 expression is essential for microtubule stabilization and mediates cilium formation. Upart from acetylation, αTAT1 interacts with doublecortin (a microtubule associated protein) to degrade microtubules that are not aligned with acetyltransferase activity. αTAT1 regulates the Wnt1 signalling pathway via β-catenin and promotes tumorigenesis. Overexpression of the ATAT1 gene is observed in colon cancer and is known to contribute to its progression.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Microtubules acquire resistance from mechanical breakage through intralumenal acetylation.
Xu Z, et al.
Science, 356(6335), 328-332 (2017)
Genetic disruption of tubulin acetyltransferase, ?TAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/?-catenin signaling.
Oh S, et al.
Biochemical and Biophysical Research Communications, 482(1), Aug-A14 (2017)
Structural basis of cofactor-mediated stabilization and substrate recognition of the ?-tubulin acetyltransferase ?TAT1.
Yuzawa S, et al.
The Biochemical Journal, 467(1), 103-113 (2015)
Tubulin acetylation: responsible enzymes, biological functions and human diseases.
Li L and Yang X J
Cellular and Molecular Life Sciences, 72(22), 4237-4255 (2015)
R A Lloyd et al.
Analytical biochemistry, 216(1), 42-46 (1994-01-01)
An assay for alpha-tubulin acetyltransferase (TAT) activity based on affinity isolation of labeled acetylated alpha-tubulin was developed for use with crude subcellular fractions. Microtubules were polymerized and immobilized on an anti-alpha-tubulin-agarose and then incubated with the subcellular fraction and [3H]acetyl-coenzyme

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