Merck

SRP0311

Sigma-Aldrich

HDAC6 H611A human

recombinant, expressed in baculovirus infected Sf9 cells, ≥79% (SDS-PAGE)

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别名:
HD6, JM21, histone deacetylase 6
NACRES:
NA.32

生物来源

human

重组

expressed in baculovirus infected Sf9 cells

检测方案

≥79% (SDS-PAGE)

形式

aqueous solution

分子量

161 kDa

包装

pkg of 50 μg

NCBI登记号

UniProt登记号

运输

dry ice

储存温度

−70°C

Gene Information

human ... HDAC6(10013)

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SRP0310SRP0111SRP0100
HDAC6 H611A human recombinant, expressed in baculovirus infected Sf9 cells, ≥79% (SDS-PAGE)

Sigma-Aldrich

SRP0311

HDAC6 H611A human

HDAC6 H216A human recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)

Sigma-Aldrich

SRP0310

HDAC6 H216A human

HDAC-9 human recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

Sigma-Aldrich

SRP0111

HDAC-9 human

HDAC-1 human recombinant, expressed in baculovirus infected insect cells, ≥50% (SDS-PAGE)

Sigma-Aldrich

SRP0100

HDAC-1 human

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

assay

≥79% (SDS-PAGE)

assay

≥75% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥50% (SDS-PAGE)

form

aqueous solution

form

aqueous solution

form

aqueous solution

form

aqueous solution

mol wt

161 kDa

mol wt

161 kDa

mol wt

50.7 kDa

mol wt

56 kDa

NCBI accession no.

NM_006044

NCBI accession no.

NM_006044

NCBI accession no.

NM_178423

NCBI accession no.

NM_004964

一般描述

HDAC6 (histone deacetylase 6) belongs to the HDAC family of proteins. HDACs are responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors. The mutation H611A results in catalytically inactive HDAC6.
Human HDAC6 with H611A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.

生化/生理作用

HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis. HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility. It is also involved in the formation of SGs (stress granules) and SG proteins. Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia.

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Li S. et al.
Neurology, 41, 112-116 (2010)
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.
Hook SS, et al.
Proceedings of the National Academy of Sciences of the USA, 99, 13425-13425 (2002)
Jiaqi Liu et al.
Journal of translational medicine, 14, 7-7 (2016-01-10)
Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been used to treat patients with melanoma. However, HDAC inhibitors are small-molecule compounds without a specific target, and their mechanism
Loss of a-Tubulin Acetylation Is Associated with TGF-?-induced Epithelial-Mesenchymal Transition.
Gu S, et al.
The Journal of Biological Chemistry, 291, 5396-5396 (2016)
A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia.
Simon D, et al.
Human Molecular Genetics, 19, 2015-2015 (2010)

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