Merck
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SRP3154

Sigma-Aldrich

sFRP-1 human

recombinant, expressed in HeLa cells, ≥97% (SDS-PAGE), ≥97% (HPLC), suitable for cell culture

所有图片(1)
别名:
SARP-2, Secreted Apoptosis Related Protein-2, Soluble Frizzled Related Protein-1

生物来源

human

重组

expressed in HeLa cells

检测方案

≥97% (HPLC)
≥97% (SDS-PAGE)

形式

lyophilized

效能

0.3-0.5 μg/mL ED50

分子量

31.0-36.0 kDa

包装

pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

杂质

<0.1 EU/μg endotoxin, tested

颜色

white

UniProt登记号

Q8N474

运输

wet ice

储存温度

−20°C

Gene Information

human ... SFRP1(6422)

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SRP3154

sFRP-1 human

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Anti-SFRP1 (C-terminal) antibody produced in goat

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SRP3187

WISP-1 human

Anti-SFRP1 antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

SAB2900383

Anti-SFRP1 antibody produced in rabbit

recombinant

expressed in HeLa cells

recombinant

-

recombinant

expressed in E. coli

recombinant

-

assay

≥97% (HPLC), ≥97% (SDS-PAGE)

assay

-

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

-

form

lyophilized

form

buffered aqueous solution

form

lyophilized

form

buffered aqueous solution

potency

0.3-0.5 μg/mL ED50

potency

-

potency

1.0-3.0 μg/mL ED50

potency

-

mol wt

31.0-36.0 kDa

mol wt

-

mol wt

38.1 kDa

mol wt

-

一般描述

The gene SFRP1 (secreted frizzled related protein 1) is mapped to human chromosome 8p22–p12, a region frequently deleted in breast cancer. It is highly expressed in normal breast tissue.

生化/生理作用

Secreted Frizzled-related protein 1 (SFRP1) is a secreted inhibitor of Wnt signaling pathway. DNA damage or oxidative stress causes cellular senescence, which leads to overexpression of sfrp1. This protein induces senescence phenotypes via the inactivation of Wnt signaling and activation of the retinoblastoma (Rb) pathway. Mutations or aberrant methylation in this gene impair the induction of senescence in several cancers, including breast cancer, bladder cancer, and colorectal tumorigenesis.

序列

SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK

外形

Lyophilized from 10 mM Sodium Phosphate pH 7.0.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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A M Goodwin et al.
Angiogenesis, 5(1-2), 1-9 (2003-01-29)
The Wnt signaling pathway regulates normal development as well as a variety of pathologies. Studies of the Wnt pathway have focused largely on very early development and on tumorigenesis. Recent observations point to a role for Wnt signaling in vessel
WNT pathway and mammary carcinogenesis: loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type.
Ugolini F
Oncogene, 20, 5810-5817 (2001)
Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers.
Yang ZQ
International Journal of Cancer. Journal International Du Cancer, 125, 1613-1621 (2009)
Xiaobin Wang et al.
Oncology letters, 4(2), 334-338 (2012-07-31)
The aims of this study were to determine the methylation and expression status of secreted Frizzled-related protein 1 (SFRP1) in bladder cancer, to explore the mechanisms involved and to study the role of SFRP1 in the pathogenesis of bladder cancer.
Germaine M Caldwell et al.
Cancer research, 64(3), 883-888 (2004-02-12)
Regions of the short arm of chromosome 8 are deleted frequently in a range of solid tumors, indicating that tumor suppressor genes reside at these loci. In this study, we have examined the properties of the Wnt signaling antagonist secreted
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