Merck
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SRP5272

Sigma-Aldrich

SIRT5，活性，His 标记 人

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

所有图片(2)
别名:
SIR2L5
NACRES:
NA.32

重组

expressed in baculovirus infected Sf9 cells

检测方案

≥70% (SDS-PAGE)

形式

buffered aqueous glycerol solution

specific activity

17.0-26.5 RLU/min·ng

分子量

~39 kDa

NCBI登记号

NM_012241

运输

dry ice

储存温度

−70°C

Gene Information

human ... SIRT5(23408)

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此商品
SRP0119SRP5273SRP5270
SIRT5, active, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5272

SIRT5，活性，His 标记 人

Sirtuin 5 human recombinant, expressed in E. coli, ≥50% (SDS-PAGE)

Sigma-Aldrich

SRP0119

Sirtuin 5 human

SIRT6, active, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5273

SIRT6, active, His tagged human

SIRT1, active, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5270

SIRT1, active, His tagged human

assay

≥70% (SDS-PAGE)

assay

≥50% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

form

aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

specific activity

17.0-26.5 RLU/min·ng

specific activity

-

specific activity

96-144 RLU/min·ng

specific activity

1573-2415 RLU/min·ng

mol wt

~39 kDa

mol wt

59.8 kDa

mol wt

~39 kDa

mol wt

~84 kDa

NCBI accession no.

NM_012241

NCBI accession no.

NM_012241

NCBI accession no.

NM_016539

NCBI accession no.

NM_012238

一般描述

SIRT5 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT5 being a member of class III. SIRT5 consists of eight exons and is found in two isoforms which encode a 310 aa and a 299 aa protein, respectively. Human SIRT5 is most predominantly expressed in heart muscle cells and in lymphoblasts. Fluorescence in situ hybridization analysis localized the human SIRT5 gene to chromosome 6p23. SIRT5 can deacetylate cytochrome c, a protein of the mitochondrial intermembrane space with a central function in oxidative metabolism as well as apoptosis initiation.

生化/生理作用

Sirtuins are NAD+-dependent deacetylases. Sirtuin 5 (SIRT5) catalyzes the degradation of negatively charged acylated substrates. It also possesses desuccinylase, demalonylase and deglutarylase activities. The protein is overexpressed in non-small cell lung cancer (NSCLC) and may have a role in cancer growth.

外形

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

制备说明

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险分类

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

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Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization.
Mahlknecht U
Cytogenetic and genome research, 112(3-4), 208-212 (2006)
Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme.
Yu J
PLoS ONE, 11(3), e0152467-e0152467 (2016)
SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.
Lu W
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 35(11), 10699-10705 (2014)
Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors.
Roessler C
Angewandte Chemie (International Edition in English), 53(40), 10728-10732 (2014)

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