Merck

SRP6002

Sigma-Aldrich

Chemerin human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

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别名:
HP10433, RARRES2, TIG2

生物来源

human

重组

expressed in E. coli

检测方案

≥98% (HPLC)
≥98% (SDS-PAGE)

形式

lyophilized

分子量

16.0 kDa

包装

pkg of 25 μg

杂质

Endotoxin, tested

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

基因信息

human ... RARRES2(5919)

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SRP6002

Chemerin human

Sigma-Aldrich

SRP3056

HVEM-Fc human

Endostatin human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

SRP3031

Endostatin human

Sigma-Aldrich

SRP3045

Follistatin human

recombinant

expressed in E. coli

recombinant

expressed in Hi-5 Insect cells

recombinant

expressed in E. coli

recombinant

expressed in E. coli

biological source

human

biological source

human

biological source

human

biological source

human

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

mol wt

16.0 kDa

mol wt

44.3 kDa

mol wt

20.2 kDa

mol wt

31.5 kDa

Gene Information

human ... RARRES2(5919)

Gene Information

human ... TNFRSF14(8764)

Gene Information

human ... COL18A1(80781)

Gene Information

human ... FST(10468)

一般描述

Chemerin, which is also known as retinoic acid receptor responder 2 (RARRES2), is a chemoattractant expressed in white adipose, liver and lung tissues. It is an immunomodulating factor. The protein is a ligand for the G-protein coupled receptor known as ChemR23 (or chemokine-like receptor-1), which is expressed mainly on dendritic cells, macrophages and some adipocytes. The gene encoding it is localized on human chromosome 7q36.1. Recombinant human Chemerin, produced in Escherichia.coli, is a non-glycosylated protein containing 138 amino acids and having a total molecular mass of 16kDa.

生化/生理作用

Chemerin activates chemerin-like receptor 1 (CMKLR1) and stimulates chemotaxis in macrophages, natural killer cells and immature dendritic cells. It is also involved in the activation of extracellular signal-regulated kinases, stimulation of blood vessel formation, migration and invasion.

外形

Lyophilized from 0.2% TFA.

重悬

Centrifuge the vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile H?O to a concentration of 0.1mg/ml, which can be further diluted into other aqueous solutions.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Jun-xian Zhou et al.
Acta pharmacologica Sinica, 35(5), 653-663 (2014-03-25)
The chemerin receptor CMKLR1 is one type of G protein-coupled receptors abundant in monocyte-derived dendritic cells and macrophages, which plays a key role in the entry of a subset of immunodeficiency viruses including HIV/SIV into lymphocytes and macrophages. The aim
Jeremy Di Domizio et al.
Nature immunology, 21(9), 1034-1045 (2020-07-15)
Skin wounds heal by coordinated induction of inflammation and tissue repair, but the initiating events are poorly defined. Here we uncover a fundamental role of commensal skin microbiota in this process and show that it is mediated by the recruitment
Association of Polymorphisms in STRA6 and RARRES2 Genes with Type 2 Diabetes in Southern Han Chinese.
Huang HW
BioMed Research International, 2016, 6589793-6589793 (2016)
Rui-Li Zhang et al.
Journal of cellular biochemistry, 120(12), 19621-19634 (2019-07-20)
Chemerin, a chemoattractant protein, is involved in endothelial dysfunction and vascular inflammation in pathological conditions. In a recent study, we observed the upregulation of chemerin in endothelial cells following in vitro treatment with Treponema pallidum. Here, we investigated the role
Chen Huang et al.
Molecular therapy oncolytics, 18, 602-612 (2020-10-03)
The adipokine chemerin has been considered an important regulator of tumor immune surveillance. Chemerin recruits leukocytes through the receptor CMKLR1 to improve clinical outcomes of tumors and overall patient survival, but the role of GPR1 in tumors has not been

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