Merck

SRP6330

Sigma-Aldrich

CD46 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

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别名:
AHUS2, MCP, MIC10, Membrane cofactor protein isoform 14, TLX, TRA2.10
NACRES:
NA.32

生物来源

human

重组

expressed in E. coli

检测方案

≥85% (SDS-PAGE)

形式

liquid

分子量

33.8 kDa (302 aa, 35-313 aa + His tag)

包装

pkg of 100 μg

浓度

1 mg/mL

杂质

<1 EU/μg endotoxin (LAL test)

UniProt登记号

运输

dry ice

储存温度

−70°C

Gene Information

human ... CD46(4179)

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此商品
SRP0584SAB1404058SAB4700432
CD46 human recombinant, expressed in E. coli, &#8805;85% (SDS-PAGE)

Sigma-Aldrich

SRP6330

CD46 human

Sigma-Aldrich

Sigma-Aldrich

SRP0584

Human CD46-C, His-Tag

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

-

recombinant

-

assay

≥85% (SDS-PAGE)

assay

-

assay

-

assay

-

form

liquid

form

frozen liquid

form

-

form

buffered aqueous solution

mol wt

33.8 kDa (302 aa, 35-313 aa + His tag)

mol wt

32.8 kDa

mol wt

antigen ~37 kDa

mol wt

-

packaging

pkg of 100 μg

packaging

-

packaging

-

packaging

-

一般描述

Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

外形

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Maximilian Richter et al.
Molecular therapy. Methods & clinical development, 5, 16013-16013 (2016-04-14)
Rituximab is a mouse/human chimeric monoclonal antibody targeted toward CD20. It is efficient as first-line therapy of CD20-positive B-cell malignancies. However, a large fraction of treated patients relapse with rituximab-resistant disease. So far, only modest progress has been made in
Yi-Jun Jia et al.
Fish & shellfish immunology, 100, 317-323 (2020-03-17)
Largemouth bass ulcerative syndrome virus (LBUSV) is an important virus induce the mortality of largemouth bass (Micropterus Salmoides). In this study, we reported a single-walled carbon nanotubes (SWCNTs) containing LBUSV major capsid protein (MCP) subunit vaccine (SWCNTs-MCP) which was evaluated
Jian Du et al.
Veterinary microbiology, 195, 87-95 (2016-10-25)
The outbreak of Chinese Giant Salamander (Andrias davidianus, CGS) Iridovirus (CGSIV) caused massive death of CGSs. However, some CGSs with low level of CGSIV usually could survive. In our study, major capsid protein (MCP) DNA replicates of CGSIV in shedding
Sinan Wang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 27(5), 1305-1315 (2020-12-10)
We recently identified CD46 as a novel therapeutic target in prostate cancer. In this study, we developed a CD46-targeted PET radiopharmaceutical, [89Zr]DFO-YS5, and evaluated its performance for immunoPET imaging in murine prostate cancer models. [89Zr]DFO-YS5 was prepared and its in
Shao-Yeh Lu et al.
Applied and environmental microbiology, 85(11) (2019-03-25)
Microcin PDI (MccPDI), a class IIa microcin that is produced by Escherichia coli strains 25 and 284, is known to inhibit foodborne pathogenic enterohemorrhagic E. coli serotypes O157:H7 and O26. Here we demonstrate that MccPDI can inhibit Shigella strains and

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