Merck

SRP6455

Sigma-Aldrich

EpCAM/CD326 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

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别名:
DIAR5, EGP2, EGP314, EGP40, ESA, GA733-2, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK1, TACSTD1, TROP1
NACRES:
NA.32

生物来源

human

重组

expressed in HEK 293 cells

标签

6-His tagged (C-terminus)

检测方案

≥95% (SDS-PAGE)

形式

lyophilized

分子量

calculated mol wt 29 kDa (after removal of signal peptide.)
observed mol wt 33-36 kDa by SDS-PAGE (DTT-reduced. rh EpCAMProtein migrates as poly peptide due to glycosylation. Gln24 is the predicted N-terminal.)

包装

pkg of 10 and 50 μg

杂质

<1 EU/μg endotoxin (LAL test)

UniProt登记号

运输

wet ice

储存温度

−20°C

Gene Information

human ... EPCAM(4072)

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SAB4700848SRP6396SAB4200690
EpCAM/CD326 human recombinant, expressed in HEK 293 cells, &#8805;95% (SDS-PAGE)

Sigma-Aldrich

SRP6455

EpCAM/CD326 human

Fc-gamma RIIB/CD32b human recombinant, expressed in HEK 293 cells, &#8805;95% (SDS-PAGE)

Sigma-Aldrich

SRP6396

Fc-gamma RIIB/CD32b human

recombinant

expressed in HEK 293 cells

recombinant

-

recombinant

expressed in HEK 293 cells

recombinant

-

assay

≥95% (SDS-PAGE)

assay

-

assay

≥95% (SDS-PAGE)

assay

-

form

lyophilized

form

buffered aqueous solution

form

lyophilized

form

buffered aqueous solution

mol wt

calculated mol wt 29 kDa (after removal of signal peptide.), observed mol wt 33-36 kDa by SDS-PAGE (DTT-reduced. rh EpCAMProtein migrates as poly peptide due to glycosylation. Gln24 is the predicted N-terminal.)

mol wt

-

mol wt

calculated mol wt 20.2 kDa, observed mol wt 23-33 kDa (DTT-reduced. Protein migrates due to different glycosylation. Ala 46 is the predicted N-terminus.)

mol wt

-

packaging

pkg of 10 and 50 μg

packaging

-

packaging

pkg of 10 and 50 μg

packaging

-

一般描述

Epithelial cell adhesion molecule (EpCAM) is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A (mAb) antigen. The gene encoding EpCAM is localized on human chromosome 2p21.

生化/生理作用

Epithelial cell adhesion molecule (EpCAM) is intricately linked with the cadherin-catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The protein has several cellular functions, like epithelial-specific cell-adhesion, cell signaling, migration, proliferation and differentiation. It is expressed in most epithelial malignancies (like epithelial ovarian cancer) and was reported as a tumor marker or a candidate of molecular targeting therapy. EpCAM cross signaling with N-cadherin involves phosphoinositide-3-kinase (Pi3K), resulting in the abrogation of the cadherin adhesion complexes in epithelial cells.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer.
Spizzo G
Gynecologic Oncology, 103(2), 483-488 (2006)
Cadherins are regulated by Ep-CAM via phosphaditylinositol-3 kinase.
Winter MJ
Molecular and Cellular Biochemistry, 302(1-2), 19-26 (2007)
The Epithelial Cell Adhesion Molecule (Ep-CAM) as a Morphoregulatory Molecule Is a Tool in Surgical Pathology
Manon J. Winter
The American Journal of Pathology, 163(6), 2139-2148 (2003)
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies
Ke Yang
Laboratory Investigation; a Journal of Technical Methods and Pathology, 96, 116-136 (2016)
Epithelial cell adhesion molecule expression (CD326) in cancer: a short review.
Patriarca C
Cancer Treatment Reviews, 38(1), 68-75 (2012)

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