所有图片(1)

SRP6516

Sigma-Aldrich

Albumin from human plasma

≥95% (SDS-PAGE)

别名:
human Albumin protein, native Albumin, human Albumin, Albumin protein, human plasma Albumin proteinHSA, native Albumin protein, human plasma
EC 号:
NACRES:
NA.32

生物来源

human

测定

≥95% (SDS-PAGE)

形式

lyophilized

分子量

66 kDa

包装

pkg of 1G

颜色

beige

UniProt登记号

运输

wet ice

储存温度

−20°C

Gene Information

human ... ALB(213)

一般描述

Human albumin is encoded by ALB gene that is mapped to human chromosome 4q. The gene is developmentally regulated and is synthesized by the liver. The encoded protein has a molar mass of 65,000 Da and consists of a single polypeptide chain of 585 amino acids.

应用

Albumin has been used in ion exchange chromatography to compare the albumin isolated from whole human plasma. It has been used to bind to phage clones in phage binding assay.

生化/生理作用

Human albumin is a globular unglycosylated serum protein that makes up for more than half of the total plasma or serum proteins. It functions in the maintenance of COP (cellular oncotic pressure). It binds to hydrophobic organic anions such as, bilirubin, long-chain fatty acids and haematin and some cations such as magnesium and calcium. It also serves as a secondary or tertiary carrier for steroids, vitamin D and thyroxine. It is involved in the catabolism of prostaglandins and metabolism of certain endogenous substances, such as lipids, and eicosanoids. It acts as a plasma buffer and scavenges oxygen free radicals, thus reducing the pathological effects of certain inflammatory diseases. Mutation in the gene coding for albumin leads to familial dysalbuminaemic hyperthyroidism.

外形

Lyophilized as a salt free solid.

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Resp. Sens. 1A

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4.
Minghetti PP
The Journal of Biological Chemistry, 261, 6747-6757 (1986)
Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma.
Travis J
The Biochemical Journal, 157, 301-306 (1976)
Albumin binding as a general strategy for improving the pharmacokinetics of proteins.
Dennis MS
The Journal of Biological Chemistry, 277, 35035-35043 (2002)
Ziying Chen et al.
Cardiovascular research, 117(3), 820-835 (2020-04-08)
Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. It has been reported that zinc is accumulated in calcified human aortic valves. However, whether zinc directly regulates CAVD is yet to be elucidated.
The role of albumin in critical illness.
Nicholson JP
British Journal of Anaesthesia, 85, 599-610 (2000)

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