Merck

T0452

Sigma-Aldrich

D-α-生育三烯酚

from rice, ≥75% (GC)

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别名:
3,4-二氢-2,5,7,8-四甲基-2-(4,8,12-三甲基-3,7,11-十三碳三烯基)-2H-1-苯并吡喃-6-醇
Empirical Formula (Hill Notation):
C29H44O2
CAS号:
分子量:
424.66
NACRES:
NA.79

生物来源

rice

质量水平

检测方案

≥75% (GC)

形式

liquid

颜色

colorless to brown

mp

30-31 °C

储存温度

−20°C

InChI

1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1

InChI key

RZFHLOLGZPDCHJ-XZXLULOTSA-N

相关类别

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此商品
T363490037768814
Sigma-Aldrich

Sigma-Aldrich

T0452

D-α-生育三烯酚

(+)-α-Tocopherol from vegetable oil, Type V, ~1000 IU/g

Sigma-Aldrich

T3634

(+)-α-生育酚

D-α-Tocotrienol analytical standard

Supelco

68814

D-α-生育三烯酚

assay

≥75% (GC)

assay

-

assay

≥96% (CP)

assay

≥97.0% (HPLC)

form

liquid

form

viscous liquid

form

liquid

form

-

color

colorless to brown

color

clear yellow to red

color

yellow to brown

color

faint beige to beige, white to yellow

mp

30-31 °C

mp

-

mp

-

mp

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

一般描述

生育三烯酚属于维生素E家族,具有不饱和类异戊二烯侧链。生育三烯酚的各种同种型在色原烷醇中的甲基取代基不同。α-粗棕榈油中的生育三烯酚是一种天然的补充剂。

生化/生理作用

α-生育三烯酚可与其他同种型一起使用以区分生育三烯酚活性。
α-生育三烯酚是一种有效的自由基清除剂,它在微粒体的氧化应激过程中引发保护功能。它是一种强效抗氧化剂,可减少炎症并用于癌症治疗。α-补充生育三烯酚可以降低高胆固醇血症中的胆固醇水平。α-生育三烯酚具有神经保护作用,因为它可阻止谷氨酸盐诱导的神经元细胞死亡。
生育三烯酚因其强抗氧化属性而被广泛使用。生育三烯酚的不同亚型在色满醇头的甲基取代上有所不同。α-生育三烯酚通过阻断神经元细胞中谷氨酸诱导的细胞死亡而表现出神经保护属性。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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(±)-α-Tocopherol synthetic, ≥96% (HPLC)

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(+)-α-Tocopherol from vegetable oil, Type V, ~1000 IU/g

Sigma-Aldrich

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(+)-α-生育酚

DL-α-Tocopherol acetate certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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δ-Tocopherol analytical standard

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(+)-α-Tocopherol Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g

Sigma-Aldrich

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(+)-α-生育酚

Han-A Park et al.
Stroke, 42(8), 2308-2314 (2011-07-02)
α-Tocotrienol (TCT) represents the most potent neuroprotective form of natural vitamin E that is Generally Recognized As Safe certified by the U.S. Food and Drug Administration. This work addresses a novel molecular mechanism by which α-TCT may be protective against
Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities
Ramanathan N, et al.
Nutrition & Metabolism, 15(1), 6-6 (2018)
Hyunil Ha et al.
Biochemical and biophysical research communications, 406(4), 546-551 (2011-03-01)
Vitamin E, an essential nutrient with powerful antioxidant activity, is the mixture of two classes of compounds, tocopherols (TPs) and tocotrienols (TTs). Although TTs exhibit better bone protective activity than α-TP, the underlying mechanism is poorly understood. In this study
Savita Khanna et al.
Journal of neurochemistry, 98(5), 1474-1486 (2006-08-23)
The natural vitamin E tocotrienols possess properties not shared by tocopherols. Nanomolar alpha-tocotrienol, not alpha-tocopherol, is potently neuroprotective. On a concentration basis, this finding represents the most potent of all biological functions exhibited by any natural vitamin E molecule. We
Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling
Packer L, et al.
The Journal of Nutrition, 131(2), 369S-373S (2001)

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