T1500

Sigma-Aldrich

睾酮

≥98%

别名:
17β-羟基-3-氧代-4-雄甾烯, 4-雄甾烯-17β-醇-3-酮, 反式-睾酮, 17β-羟基-4-雄甾烯-3-酮
Empirical Formula (Hill Notation):
C19H28O2
CAS号:
分子量:
288.42
Beilstein/REAXYS Number:
1915399
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

200

生物来源

synthetic (organic)

无菌性

non-sterile

测定

≥98%

形式

powder

drug control

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

溶解性

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 18.2 mg/ml
absolute ethanol: soluble 0.5 mg/ml
chloroform: soluble 100 mg/mL, clear, colorless to very faintly yellow
H2O: insoluble
dioxane: soluble
methanol: soluble
methyl oleate: slightly soluble
vegetable oils: soluble

运输

ambient

储存温度

room temp

SMILES string

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

InChI key

MUMGGOZAMZWBJJ-DYKIIFRCSA-N

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应用

睾丸激素已被用作研究雄性和雌性大鼠大脑中类固醇激素发育情况的标准品。该激素也已用于评估其对小鼠肌肉质量和信号传导的作用。

生化/生理作用

睾丸分泌的睾酮在具有协调多种睾酮生物作用的目标组织中被转化为双氢睾酮。雄激素在胚胎形成过程中以及青春期引导男性表型的发育。

制备说明

睾丸激素以 100 mg/ml 的浓度溶于氯仿中,得到透明、无色至微弱的黄色溶液。它也可溶于甲醇、无水乙醇(0.5 mg/ml)、45%(w/v)2-羟丙基-b-环糊精水溶液(18.2 mg/ml)、植物油和二恶烷。微溶于油酸甲酯,不溶于水。

警示用语:

Danger

个人防护装备

Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RIDADR

UN 3077 9 / PGIII

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the method of production for Product T1500, Testosterone?

    This information is listed on the product's Certificate of Origin, which is lot-specific and, thus, subject to change. Enter the lot number of interest into the Certificate of Origin search box on the product page to find this information.

  6. How long can I store a solution of Product T1500, Testosterone?

    We have not determined the solution stability of this product. As a guideline, please note the stability of product no. T5411, Testosterone solution 1.0 mg/mL, which is stable for  3 years at 2-8 C.

  7. What can I use to prepare a solution of Product T1500, Testosterone?

    The product is soluble in absolute ethanol (0.5 mg/ml), It is also soluble in vegetable oils, soluble in dioxan and slightly soluble in methyl oleate.

  8. It is possible to sterile filter a solution of Product T1500, Testosterone?

    A solution of testosterone cannot be sterile filtered, since the compound will stick to the filter paper, according to Sigma cell culture scientists' experience.

  9. How could I dissolve Product T1500, Testosterone for cell culture use?

    This product has not been tested for cell culture use. We offered Testosterone for cell culture, now discontinued, and for it our 1998 Sigma Cell Culture advised to dissolve 1 mg in 2.0 mL absolute ethanol, gently swirl to dissolve, then add 48 mL sterile medium to prepare 20 ug/ml stock solution. Working range: 20-300 ng/ml.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Chikwendu Ibebunjo et al.
American journal of physiology. Endocrinology and metabolism, 300(2), E327-E340 (2010-11-04)
Declines in skeletal muscle size and strength, often seen with chronic wasting diseases, prolonged or high-dose glucocorticoid therapy, and the natural aging process in mammals, are usually associated with reduced physical activity and testosterone levels. However, it is not clear...
Anne T M Konkle et al.
Endocrinology, 152(1), 223-235 (2010-11-12)
The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex...
Frances S Chen et al.
Social cognitive and affective neuroscience, 10(6), 797-800 (2014-09-07)
Physical size and strength are associated with dominance and threat. The current study tested (i) whether men's evaluations of male strangers would be negatively influenced by cues indicating physical formidability, and (ii) whether these evaluations would be influenced by oxytocin...
Jianzhen Li et al.
Biology of reproduction, 100(2), 468-478 (2018-11-13)
The role of androgenic steroids on ovarian development has attracted much attention in recent years, but the molecular mechanism is still largely unknown. In this study, using zebrafish as a model, we found that the trace metal zinc mediates the...
James R Bell et al.
American journal of physiology. Heart and circulatory physiology, 306(9), H1265-H1274 (2014-03-13)
Estrogen in females is conventionally considered a cardioprotective influence, but a role for estrogen in male cardioprotection has yet to be defined. Estrogen biosynthesis from testosterone is regulated by aromatase. Aromatase has recently been shown to be expressed in the...

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