T3067

Sigma-Aldrich

Monoclonal Anti-TRAIL antibody produced in mouse

clone 75411, purified immunoglobulin, lyophilized powder

别名:
Anti-TNFSF10, Anti-TNF-Related Apoptosis-Inducing Ligand
MDL number:
NACRES:
NA.41

Quality Level

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

75411, monoclonal

form

lyophilized powder

species reactivity

human

application(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 8-25 μg/mL using human brain (occipital cortex) tissue sections
neutralization: 28 ng/mL using L929 mouse fibroblast cell line

isotype

IgG1

conjugate

unconjugated

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... TNFSF10(8743)

Immunogen

purified, NSO-derived, recombinant human TRAIL extracellular domain.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Shashank Tummala et al.
Artificial cells, nanomedicine, and biotechnology, 44(8), 1835-1850 (2015-12-25)
Conventional chemotherapy majorly lacks clinical application attributed to its inspecificity, adverse effects and inability to penetrate into tumor cells. Hence, the aim of the study was to prepare oxaliplatin solid lipid nanoparticles (OP-SLN) by microemulsion method optimizing it by Box-Behnken...
ZhengQiang Yuan et al.
Journal of extracellular vesicles, 6(1), 1265291-1265291 (2017-03-23)
Extracellular vesicles (EVs) are lipid membrane-enclosed nanoparticles released by cells. They mediate intercellular communication by transferring biological molecules and therefore have potential as innovative drug delivery vehicles. TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis of cancer cells. Unfortunately, the clinical...
S R Wiley et al.
Immunity, 3(6), 673-682 (1995-12-01)
A novel tumor necrosis factor (TNF) family member has been cloned and characterized. This protein, designated TNF-related apoptosis-inducing ligand (TRAIL), consists of 281 and 291 aa in the human and murine forms, respectively, which share 65% aa identity. TRAIL is...
R M Pitti et al.
The Journal of biological chemistry, 271(22), 12687-12690 (1996-05-31)
Cytokines in the tumor necrosis factor (TNF) family regulate development and function of the immune system. We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag. Apo-2L is a 281-amino acid protein...
ZhengQiang Yuan et al.
Cytotherapy, 17(7), 885-896 (2015-04-19)
Mesenchymal stromal cell (MSC) delivery of pro-apoptotic tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an attractive strategy for anticancer therapy. MSCs expressing full-length human TRAIL (flT) or its soluble form (sT) have previously been shown to be effective for...

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