T6199
抗-α-微管蛋白抗体，小鼠单克隆
clone DM1A, purified from hybridoma cell culture
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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
antibody product type
primary antibodies
克隆
DM1A, monoclonal
形式
buffered aqueous solution
分子量
antigen ~50 kDa
species reactivity
yeast, mouse, amphibian, human, rat, chicken, fungi, bovine
包装
antibody small pack of 25 μL
增强验证
independent ( Antibodies)
Learn more about Antibody Enhanced Validation
浓度
~1 mg/mL
technique(s)
immunocytochemistry: 0.5-1 μg/mL using cultured chicken fibroblasts (CFB)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.5-1 μg/mL using total tissue extract from chicken gizzard
同位素/亚型
IgG1
UniProt登记号
application(s)
research pathology
运输
dry ice
储存温度
−20°C
Gene Information
human ... TUBA4A(7277)
mouse ... Tuba1a(22142)
rat ... Tuba1a(64158)
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This Item | T0198 | T7451 | T6074 |
|---|---|---|---|
| biological source mouse | biological source mouse | biological source mouse | biological source mouse |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| antibody form purified immunoglobulin | antibody form purified immunoglobulin | antibody form purified immunoglobulin | antibody form purified from hybridoma cell culture |
| clone DM1A, monoclonal | clone D66, monoclonal | clone 6-11B-1, monoclonal | clone B-5-1-2, monoclonal |
| form buffered aqueous solution | form buffered aqueous solution | form buffered aqueous solution | form buffered aqueous solution |
| mol wt antigen ~50 kDa | mol wt antigen ~50 kDa | mol wt - | mol wt antigen ~50 kDa |
一般描述
微管蛋白是微管的主要组成部分。这种细胞内圆柱形丝状结构存在于几乎所有的真核细胞中。微管在细胞有丝分裂、胞内运输、鞭毛运动和细胞骨架中起着结构和活动的作用。微管蛋白是一个异源二聚体，包含α-微管蛋白和β-微管蛋白。两个亚基的相对分子质量都约为50 kDa，具有相当大的同源性。除了α-和β-微管蛋白外，其他几个微管蛋白已被确定，使各种微管蛋白类的数量达到7种。这些微管蛋白大多具有明显的亚细胞定位和一系列明显不同的功能。七种不同的微管蛋白家族中有四个成员是近期被鉴定得到的，包括δ, ξ, η和ε-微管蛋白。η和ε-微管蛋白是由数据库搜索得到。微管系统至少含有三种α-微管蛋白异构体。两种异构体由两个α-微管蛋白基因编码，这两个基因都是转录并编码极其相似的蛋白质。第三种异构体是通过翻译后修饰形成的。至少有三种微管蛋白亚基的修饰过程已得到描述：大脑中β-微管蛋白的磷酸化，脊椎动物组织中去除羧基末端酪氨酸形成的a-微管蛋白，以及α-微管蛋白中赖氨酸氨基的乙酰化。
α-微管蛋白，又称微管蛋白 α 4a (TUBA4A),定位于人类基因组2q35。该基因编码α-微管蛋白家族的一个成员，该成员含448个氨基酸。微管蛋白的α-亚基的分子量为50000。
识别α-微管蛋白的单克隆抗体与其他微管蛋白亚型的单克隆抗体一起(β，β-微管蛋白亚型I +II， β-微管蛋白亚型III，酪氨酸微管蛋白，α-微管蛋白的乙酰化形式)为研究微管蛋白在细胞内的分布以及细胞骨架的静态和动态方面提供了一种特异的且重要工具。
特异性
免疫原
应用
生化/生理作用
α-微管蛋白或α 4A(TUBA4A)在细胞生长和分裂中起重要作用。它还参与各种细胞过程，如细胞活力，信号发展和细胞形状的维持。TUBA4A基因突变与多种癌症的发生有关，如口腔癌、乳腺癌、直肠癌、肺癌和前列腺癌。此外，TUBA4A的变异可导致偶发性肌萎缩侧索硬化症(ALS)。
外形
制备说明
其他说明
免责声明
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(F)
Not applicable
闪点(C)
Not applicable
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