Merck
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T9033

Sigma-Aldrich

毒胡萝卜素

≥98% (HPLC), solid film

Empirical Formula (Hill Notation):
C34H50O12
CAS Number:
Molecular Weight:
650.75
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

300

生物来源

plant (Thapsia garganica)

测定

≥98% (HPLC)

形式

solid film

溶解性

acetonitrile: soluble 9.80-10.20 mg/mL
DMSO: soluble
ethanol: soluble

储存温度

−20°C

SMILES string

[H][C@@]12C([C@H](OC([C@]3(O)C)=O)[C@]3(O)[C@@H](OC(CCC)=O)C[C@]2(C)OC(C)=O)=C(C)[C@H](OC(/C(C)=C(C)/[H])=O)[C@H]1OC(CCCCCCC)=O

InChI

1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1

InChI key

IXFPJGBNCFXKPI-FSIHEZPISA-N

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应用

Thapsigargin has been used to study the consequences of calcium depletion in the endoplasmic reticulum (ER) of cells. Thapsigargin has also been used to study its effect on tissue inhibitor of metalloproteinases-1 (TIMP-1) mRNA expression in rat Sertoli cells.

生化/生理作用

强有效的可穿透细胞的IP3-依赖型细胞内钙释放器。 阻断由血管抑制素和内皮抑素诱导的细胞内Ca2+的瞬时增加。 通过破坏细胞内游离Ca2+水平诱导细胞凋亡;掺入进化学治疗前药的配方中。

象形图

Exclamation markHealth hazard

警示用语:

Danger

危险分类

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

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