Merck
所有图片(4)

U2625

Sigma-Aldrich

尿酸

≥99%, crystalline

别名:
2,6,8-三羟基嘌呤
Empirical Formula (Hill Notation):
C5H4N4O3
CAS号:
分子量:
168.11
Beilstein:
156158
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.55

质量水平

100

测定

≥99%

形式

crystalline

mp

>300 °C (lit.)

SMILES string

O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

InChI key

LEHOTFFKMJEONL-UHFFFAOYSA-N

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应用

尿酸可以用于:
  • 诱导小鼠高尿酸血症
  • 作为刺激体外人消化模型的消化液组分
  • 选择性检测基于汗液的糖尿病监测葡萄糖感应器

包装

25, 100 g in poly bottle
1 kg in poly bottle

生化/生理作用

尿酸是一种腺嘌呤和鸟嘌呤产生的不溶性分解代谢物。尿酸积累导致痛风,高尿酸血症,关节炎和肾功能衰竭。尿酸水平升高导致高血压与心血管疾病发病。低尿酸水平和帕金森症和多发性硬化有关,可能引发保护性功能。慢性阻塞性肺(COPD)病人高水平尿酸可用作潜在诊疗标记物。

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书

请输入批号搜索分析证书(COA)。

原产地证书 (CofO)

请输入批号搜索原产地证书(COO)。

Reduction of Serum Uric Acid Associated with Attenuation of Renal Injury, Inflammation and Macrophages M1/M2 Ratio in Hyperuricemic Mice Model
HARYONO A, et al.
Kobe J. Med. Sci., 64(3), E107-E114 (2018)
Uric acid in plants and microorganisms: Biological applications and genetics-A review
Hafez RM, et al.
Journal of Advanced Research, 8(5), 475-486 (2017)
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
Lee H, et al.
Nature Nanotechnology, 11(6), 566-566 (2016)
Serum uric acid: a risk factor and a target for treatment?
Feig DI, et al.
Journal of the American Society of Nephrology, 17(4), S69-S73 (2006)
Uric acid, hyperuricemia and vascular diseases
Jin M, et al.
Frontiers in Bioscience, 17, 656-656 (2012)

技术文章

Uric Acid in Cell Culture

Uric acid is not a direct additive to any of the classical cell culture media. However, it is present in animal sera. Consequently, uric acid is typically present in complete serum-supplemented classical cell culture systems.

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