Merck

U6253

Sigma-Aldrich

Ubiquitin 来源于牛红细胞

BioUltra, ≥98% (SDS-PAGE), essentially salt-free, lyophilized powder

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别名:
ATP依赖性蛋白水解因子, Ub
CAS号:
MDL编号:
NACRES:
NA.32

生物来源

bovine erythrocytes

质量水平

产品线

BioUltra

检测方案

≥98% (SDS-PAGE)

形式

essentially salt-free, lyophilized powder

储存条件

(Tightly closed. Dry)

technique(s)

western blot: suitable

杂质

salt, essentially free

溶解性

water: 1 mg/mL, clear, colorless

UniProt登记号

储存温度

2-8°C

Gene Information

bovine ... LOC(101902760)

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此商品
U5382P1431C6905
Ubiquitin human ≥95% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal FLAG® tagged), essentially salt-free, lyophilized powder

Sigma-Aldrich

U5382

泛素 人

assay

≥98% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

≥98% (PAGE)

form

essentially salt-free, lyophilized powder

form

essentially salt-free, lyophilized powder

form

lyophilized powder

form

essentially salt-free, lyophilized powder

storage condition

(Tightly closed. Dry)

storage condition

-

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

storage condition

-

technique(s)

western blot: suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

ligand binding assay: suitable

technique(s)

activity assay: suitable

impurities

salt, essentially free

impurities

-

impurities

salt, essentially free

impurities

-

一般描述

研究领域:癌症

泛素是一种高度保守的调控蛋白。它存在于所有真核细胞中,在包括酵母、人类和植物在内的所有生命形式中几乎是相同的。泛素结构包含7个赖氨酸残基和一个N末端,这些都是泛素化的靶点。

应用

来自牛红细胞的泛素已用于研究外源性泛素在慢性β肾上腺素受体(β-AR)刺激的心肌重构中的作用。它还被用作测试核因子kappa-B激酶亚基β(IKKβ)泛素化的抑制剂。

来自牛红细胞的泛素可用于体外泛素化检测。该产品还可以用作蛋白质印迹的标记物。

生化/生理作用

泛素化是泛素蛋白与底物蛋白结合的翻译后修饰过程。泛素化在细胞凋亡、蛋白质加工、免疫反应、DNA修复等生物学过程中对细胞信号传导的调控起着重要作用。泛素化通过泛素-蛋白酶体途径介导蛋白质降解。泛素化作用涉及多种细胞信号传导途径。多聚泛素化可调节炎症信号传导途径中NF-κ-B抑制剂α(IkB-α)的信号激活。在很多疾病中都可观察到泛素水平的升高,比如寄生虫病和过敏性疾病、酒精性肝病、ii型糖尿病、2-微球蛋白淀粉样变tβ2-微球蛋白淀粉样变以及慢性血液透析等。

制备说明

牛红细胞中的泛素可以1 mg/ml的量溶于水中,产生澄清无色的溶液。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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其他客户在看

Slide 1 of 3

1 of 3

Biochemistry, Ubiquitination
Guo HJ, et al.
StatPearls [Internet] (2022)
Christopher R Daniels et al.
American journal of physiology. Heart and circulatory physiology, 303(12), H1459-H1468 (2012-10-09)
β-Adrenergic receptor (β-AR) stimulation increases extracellular ubiquitin (UB) levels, and extracellular UB inhibits β-AR-stimulated apoptosis in adult cardiac myocytes. This study investigates the role of exogenous UB in chronic β-AR-stimulated myocardial remodeling. l-Isoproterenol (ISO; 400 μg·kg(-1)·h(-1)) was infused in mice
A L Schwartz et al.
Annual review of medicine, 50, 57-74 (1999-03-12)
The ubiquitin-proteasome pathway plays a pivotal role in the degradation of short-lived and regulatory proteins important in a variety of basic cellular processes, including regulation of the cell cycle, modulation of cell surface receptors and ion channels, and antigen presentation.
Takeshi Miura et al.
FEMS microbiology letters, 239(1), 171-179 (2004-09-29)
When Saccharomyces cerevisiae cells are exposed to high hydrostatic pressure, tryptophan permease Tat2 is degraded in a manner dependent on Rsp5 ubiquitin ligase. Consequently, cell growth is arrested in tryptophan auxotrophic strains. Here we show that of 17 ubiquitin-specific protease
The ubiquitin system for protein degradation.
A Hershko et al.
Annual review of biochemistry, 61, 761-807 (1992-01-01)

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