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V2876

Sigma-Aldrich

维生素 B 12

≥98%

别名:
Cyanocob(III)alamin, 氰钴胺, α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl
Empirical Formula (Hill Notation):
C63H88CoN14O14P
CAS号:
分子量:
1355.37
Beilstein:
4122889
EC 号:
eCl@ss:
34058004
PubChem化学物质编号:
NACRES:
NA.79

质量水平

200

生物来源

synthetic (organic)

测定

≥98%

形式

powder

应用

HPLC: suitable

颜色

red to brown

储存温度

2-8°C

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

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相关类别

应用

维生素B12已可用于:
  • 体外 肠道模拟试验中作为维生素混合溶液的成分
  • 作为尺寸排阻电感耦合等离子体质谱(SEC-ICP-MS)的标准
  • 作为模拟血浆蛋白混合物的组成部分,用于拉曼光谱分析
  • 在表面等离子体共振(SPR)分析中
  • 作为新生大鼠心室肌细胞(NRVM)的培养基补充物

包装

1, 5, 25 g in glass bottle
100, 250, 500 mg in glass bottle

生化/生理作用

维生素B12(钴胺)是指一组化学相关的钴分子,参与细胞的DNA合成、脂肪酸合成、能量生产和调控等过程。 生理活性形式的维生素B12包括甲基钴胺和腺苷钴胺,而羟钴胺(维生素B12a, OHCbl)和氰钴胺(CNCbl)是储存和运输形式。 细菌衍生的羟钴胺(OHCbl)和CNCbl在人体中转化为可用的辅酶形式,以支持代谢过程。如线粒体甲基丙二酸甲酯辅酶A突变酶可将甲基丙二酸甲酯转化为琥珀酸,以连接脂质和碳水化合物代谢,激活蛋氨酸合成酶——这是合成蛋氨酸的限速步骤。

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 1

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书

原产地证书 (CofO)

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How should I store a solution of Vitamin B12, Product V2876?

    Serum Vitamin B12 is highly unstable and should be protected from light and kept frozen. Cyanocobalamin is often used to supplement media. It has a maximal stability at pH = 7, but is photolysed to hydroxocobalamin with a zero-order rate constant.

  6. Vitamin B12, Product V2876, is produced by fermentation.  What bacteria is used to produce this product?

    The bacterial source for this product is considered proprietary.

  7. What can I use to make a solution of Vitamin B12, Product V2876?

    The specification sheet for Product V2876 (available from the product page on the website) indicates that the product is soluble in water (50 mg/mL), yielding a dark red solution.

  8. What is the Extinction Coefficient for Vitamin B12, Product V2876?

    Extinction Coefficient: E1% = 64 (550 nm), 204 (361 nm), 115 (278 nm) in water.  Extinction Coefficient: EmM = 27.5 (361 nm) in water.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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