Merck
All Photos(7)

V2876

Sigma-Aldrich

维生素 B 12

≥98%

Synonym(s):
α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, 氰钴胺
Empirical Formula (Hill Notation):
C63H88CoN14O14P
CAS Number:
Molecular Weight:
1355.37
Beilstein:
4122889
EC 号:
eCl@ss:
34058004
PubChem化学物质编号:
NACRES:
NA.79

生物来源

synthetic (organic)

质量水平

检测方案

≥98%

形式

powder

technique(s)

HPLC: suitable

颜色

red to brown

储存温度

2-8°C

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

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1 of 4

This Item
6791V66291.24592
Vitamin B12 ≥98%

Sigma-Aldrich

V2876

维生素 B 12

Millipore

Millipore

6791

Vitamin B12

Vitamin B12 BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

Sigma-Aldrich

V6629

维生素 B 12

Millipore

Millipore

1.24592

Vitamin B₁₂

biological source

synthetic (organic)

biological source

-

biological source

microbial

biological source

-

assay

≥98%

assay

≥95% dry basis (UV)

assay

≥98%

assay

-

form

powder

form

powder

form

powder

form

solid

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

-

color

red to brown

color

red-purple

color

red to brown

color

-

storage temp.

2-8°C

storage temp.

15-25°C

storage temp.

2-8°C

storage temp.

15-25°C

应用

维生素B12已可用于:
  • 体外 肠道模拟试验中作为维生素混合溶液的成分
  • 作为尺寸排阻电感耦合等离子体质谱(SEC-ICP-MS)的标准
  • 作为模拟血浆蛋白混合物的组成部分,用于拉曼光谱分析
  • 在表面等离子体共振(SPR)分析中
  • 作为新生大鼠心室肌细胞(NRVM)的培养基补充物

生化/生理作用

维生素B12(钴胺)是指一组化学相关的钴分子,参与细胞的DNA合成、脂肪酸合成、能量生产和调控等过程。 生理活性形式的维生素B12包括甲基钴胺和腺苷钴胺,而羟钴胺(维生素B12a, OHCbl)和氰钴胺(CNCbl)是储存和运输形式。 细菌衍生的羟钴胺(OHCbl)和CNCbl在人体中转化为可用的辅酶形式,以支持代谢过程。如线粒体甲基丙二酸甲酯辅酶A突变酶可将甲基丙二酸甲酯转化为琥珀酸,以连接脂质和碳水化合物代谢,激活蛋氨酸合成酶——这是合成蛋氨酸的限速步骤。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

个人防护装备

Eyeshields, Gloves, type N95 (US)


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