Z0878

Sigma-Aldrich

敏喘宁

solid

别名:
1,4-二氢-5-(2-丙氧苯基)-7H-1,2,3-三唑并 (4,5-d) 嘧啶-7-酮
Empirical Formula (Hill Notation):
C13H13N5O2
CAS号:
分子量:
271.27
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

form

solid

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL
DMSO: 10 mg/mL
H2O: insoluble

SMILES string

CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2

InChI

1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)

InChI key

REZGGXNDEMKIQB-UHFFFAOYSA-N

Gene Information

human ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144)

Application

扎普司特已被用于通过生发泡破裂(GVBD)检测测定其对卵母细胞减数分裂的影响,并用于通过免疫组织化学测试其对视网膜细胞的抑制作用。

Packaging

25, 100 mg in poly bottle

Biochem/physiol Actions

扎普司特对磷酸二酯酶10和11(PDE10和PDE11)没有实质性的抑制作用。它还具有血管舒张作用。
cGMP 特异性磷酸二酯酶 V 和 VI (PDE5/6) 选择性抑制剂和 G 蛋白偶联受体 35 (GPR35) 激动剂。

Features and Benefits

该化合物也是 Sigma 药理活性化合物库(LOPAC®1280)的一部分,该库是一个生物学注释的高品质、可即时筛选化合物的集合。点击此处了解更多信息。

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Xinhua Zhang et al.
American journal of physiology. Endocrinology and metabolism, 302(2), E243-E253 (2011-10-27)
Testosterone (T) plays a permissive role in the development of benign prostatic hyperplasia (BPH), and phosphodiesterase 5 inhibitors (PDE5is) have been found to be effective for BPH and lower urinary tract symptoms (LUTS) in clinical trials. This study investigated the...
Selective pulmonary vasodilation induced by aerosolized zaprinast
Ichinose F, et al.
Anesthesiology, 88(2), 410-416 (1998)
Cristina Cosi et al.
Neuropharmacology, 60(7-8), 1227-1231 (2010-11-30)
G-protein coupled receptor 35 (GPR35) is a former "orphan receptor" expressed in brain and activated by either kynurenic acid or zaprinast. While zaprinast has been studied as a phosphodiesterase inhibitor, kynurenic acid (KYNA) is a tryptophan metabolite and has been...
Barbara Picconi et al.
Brain : a journal of neurology, 134(Pt 2), 375-387 (2010-12-25)
The aim of the present study was to evaluate the role of the nitric oxide/cyclic guanosine monophosphate pathway in corticostriatal long-term depression induction in a model of levodopa-induced dyskinesia in experimental parkinsonism. Moreover, we have also analysed the possibility of...
L Santschi et al.
Journal of neurophysiology, 82(3), 1577-1589 (1999-09-14)
Although it is widely agreed that cyclic AMP is necessary for the full expression of long-term potentiation of synaptic strength, it is unclear whether cyclic AMP or cyclic AMP-dependent protein kinase (PKA) play roles in the induction of long-term depression...

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