Merck

ZRB1042

Sigma-Aldrich

Anti-Somatostatin-28 Antibody, clone 2B19 ZooMAb® Rabbit Monoclonal

enhanced validationgreener alternative

recombinant, expressed in HEK 293 cells

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别名:
Growth hormone release-inhibiting factor, Somatostatin

生物来源

rabbit

质量水平

重组

expressed in HEK 293 cells

偶联物

unconjugated

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

2B19, recombinant monoclonal
monoclonal

产品线

ZooMAb® learn more

形式

lyophilized

分子量

calculated mol wt 12.73 kDa (for Somatostatin)

种属反应性

human

种属反应性(根据同源性预测)

rat, sheep, bovine, mouse

包装

antibody small pack of 25 μL

环保替代产品特性

Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

增强验证

recombinant expression
Learn more about Antibody Enhanced Validation

技术

affinity binding assay: suitable
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

同位素/亚型

IgG

UniProt登记号

环保替代产品分类

运输

ambient

储存温度

2-8°C

靶向翻译后修饰

unmodified

基因信息

human ... SST(6750)

一般描述

We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Green Chemistry.This antibody is Preservative-free, produced without the harm or sacrifice of animals and exceptionally stable to allow for ambient shipping and storage if needed and thus aligns with "Waste Prevention", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here for more information.
ZooMAb antibodies represent an entirely new generation of recombinant monoclonal antibodies.

Each ZooMAb antibody is manufactured using our proprietary recombinant expression system, purified to homogeneity, and precisely dispensed to produce robust and highly reproducible lot-to-lot consistency. Only top-performing clones are released for use by researchers. Each antibody is validated for high specificity and affinity across multiple applications, including its most commonly used application. ZooMAb antibodies are reliably available and ready to ship when you need them.

Learn more about ZooMAb here.

特异性

Clone 8G9.2 is a ZooMAb mouse recombinant monoclonal antibody that specifically detects human Somatstatin-28.

免疫原

KLH-conjugated linear peptide corresponding to 17 amino acids from human Somatistatin-28 (C-terminal region of somatostatin).

应用

Anti-Somatostatin-28, clone 2B19 ZooMAb, Cat. No. ZRB1042, is a recombinant Rabbit monoclonal antibody that targets Somatostatin-28 and is tested for use in Affinity Binding Assay, Immunofluorescence, and Immunohistochemistry (Paraffin).
Immunofluorescence Analysis: A 1:100 dilution from a representative lot detected Somatostatin-28 in human pancreas tissue sections.

Affinity Binding Assay: A representative lot of this antibody bound human Somatostatin-28 peptide with a KD of 1.1 x 10-7 in an affinity binding assay.

Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user

目标描述

Somatostatin (UniProt: P61278; also known as Growth hormone release-inhibiting factor) is encoded by the SST gene (Gene ID: 6750) in human. Somatostatin, a tetradecapeptide, displays highest expression in the islets of Langerhans and in the brain. It is synthesized with a signal peptide (aa 1-24), which is subsequently cleaved off and the remaining chain can cleave into three chains: Neuronostatin (aa 31-43), Somatostatin-28 (aa 89-116), and Somatostatin-14 (aa 103-116). Somatostatin-28 is mainly produced by the intestinal enteroendocrine cells and somatostatin-14 is the predominant form present in the brain. Neuronostatin is believed to enhance low-glucose-induced glucagon release by pancreatic alpha cells. Somatostatin is shown to Inhibit the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. In the intestine it exerts inhibitory effects on various gastrointestinal functions, including gastric acid secretion, gastric emptying, intestinal motility, and release of various gastrointestinal hormones. Somatostatin actions are mediated through five distinct receptor subtypes known as SST1-5 that are G-protein coupled receptors. SST2 and 5 are shown to be the main mediators of the gastrointestinal effects of somatostatin. This ZooMAb recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals.

外形

Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS with 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.

重悬

30 μg/mL after reconstitution at 25 μL per vial. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.

储存及稳定性

Recommend storage of lyophilized product at 2-8°C; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8°C, or -20°C for long term storage. Avoid repeated freeze-thaws.

法律信息

ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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