Merck

1133547

USP

氯化胆碱

United States Pharmacopeia (USP) Reference Standard

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别名:
(2-羟乙基)三甲基氯化铵
线性分子式:
(CH3)3N(Cl)CH2CH2OH
CAS号:
分子量:
139.62
Beilstein:
3563126
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

pharmaceutical primary standard

manufacturer/tradename

USP

mp

302-305 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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PHR1251C7017PHG0021
Choline chloride United States Pharmacopeia (USP) Reference Standard

USP

1133547

氯化胆碱

Choline chloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1251

氯化胆碱

Choline chloride ≥99%

Sigma-Aldrich

C7017

氯化胆碱

Choline chloride

SAFC

PHG0021

氯化胆碱

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

format

neat

format

neat

format

-

format

-

mp

302-305 °C (dec.) (lit.)

mp

302-305 °C (dec.) (lit.)

mp

302-305 °C (dec.) (lit.)

mp

302-305 °C (dec.) (lit.)

一般描述

本产品按照发行药典的发行和规定提供。支持本产品的所有信息,包括安全数据表和任何产品信息传单,都是在发行药典的授权下开发和发布的。如需进一步信息和支持,请访问现行药典网站。

生化/生理作用

丁酰胆碱酯酶(BChE)和对氧磷酯酶1(PON1)是由肝脏合成的并且与炎症相关的血清酶,这两种酶在注射LPS的脓毒症动物模型中的活性降低。氯化胆碱以20mg/kg体重的剂量静脉注射给药,可防止LPS介导的BChE和PON1酶活性降低 。

底物

胆碱乙酰基转移酶底物

分析说明

这些产品仅供测试和化验使用。它们不适用于人类或动物,也不能用于诊断、治疗或治愈任何类型的疾病。

其他说明

USP颁布的SDS请点击此处
可能适用相应的销售限制。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable


Certificates of Analysis (COA)

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Xinyin Jiang et al.
Journal of cellular physiology, 229(8), 1016-1027 (2014-03-22)
Maternal choline intake during gestation may influence placental function and fetal health outcomes. Specifically, we previously showed that supplemental choline reduced placental and maternal circulating concentrations of the anti-angiogenic factor, fms-like tyrosine kinase-1 (sFLT1), in pregnant women as well as
Zhuo Li et al.
Biochimica et biophysica acta, 1840(7), 2112-2122 (2014-03-19)
Choline kinase has three isoforms encoded by the genes Chka and Chkb. Inactivation of Chka in mice results in embryonic lethality, whereas Chkb(-/-) mice display neonatal forelimb bone deformations. To understand the mechanisms underlying the bone deformations, we compared the
Francina Agosti et al.
The European journal of neuroscience, 40(5), 2755-2765 (2014-06-20)
The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor involved in food intake and energy expenditure regulation. MC4R activation modifies neuronal activity but the molecular mechanisms by which this regulation occurs remain unclear. Here, we tested the hypothesis that
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The microenvironment is increasingly recognized as a crucial aspect of cancer. In contrast and complement to the field's focus on biochemical factors and extracellular matrix, we characterize a novel aspect of host:tumor interaction - endogenous bioelectric signals among non-excitable somatic
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In eukaryotic cells, phospholipids are synthesized exclusively in the defined organelles specific for each phospholipid species. To explain the reason for this compartmental specificity in the case of phosphatidylcholine (PC) synthesis, we constructed and characterized a Saccharomyces cerevisiae strain that

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