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Sushma Singh et al.
Rheumatology international, 34(10), 1395-1400 (2014-04-11)
MicroRNAs (miRNAs) are non-coding RNA that modulate the expression of multiple target genes at the post-transcriptional level. Single-nucleotide polymorphisms (SNPs) in pre-miRNAs can alter miRNA expression, and polymorphism in target molecules can affect binding to target mRNA. Studies have shown...
Jeffrey R Bishop et al.
Psychopharmacology, 232(1), 145-154 (2014-08-07)
Type-3 metabotropic glutamate receptor gene (GRM3) single nucleotide polymorphisms (SNPs) have been associated with cognitive performance and prefrontal cortex brain activity in chronically treated schizophrenia patients. Whether these SNPs are associated with cognitive and symptom response to antipsychotic therapy has...
Jianfei Xue et al.
Nature communications, 6, 6156-6156 (2015-02-03)
Aberrant activation of β-catenin in the nucleus has been implicated in a variety of human cancers, but the fate of nuclear β-catenin is unknown. Here we demonstrate that the tripartite motif-containing protein 33 (TRIM33), acting as an E3 ubiquitin ligase...
Christine Schulze et al.
Molecular nutrition & food research, 58(9), 1795-1808 (2014-07-31)
There is a growing interest in food constituents that could reduce intestinal glucose absorption to prevent overshooting plasma glucose and insulin levels in patients with prediabetes and diabetes mellitus type 2. We here demonstrate that an extract and individual polyphenols...
Xiang-en Meng et al.
Cellular and molecular neurobiology, 35(2), 159-165 (2014-09-06)
The aim of the present study was to investigate the relationship between acute ischemic stroke and glutamate levels and to determine the prognosis value of plasma glutamate levels to predict the functional outcome. Two hundred and forty-two patients with acute...
Jeannette Werner et al.
Nucleic acids research, 42(21), 13061-13073 (2014-11-13)
Engineered transcription activator-like effectors, or TALEs, have emerged as a new class of designer DNA-binding proteins. Their DNA recognition sites can be specified with great flexibility. When fused to appropriate transcriptional regulatory domains, they can serve as designer transcription factors...
Sophea Heng et al.
Analytical biochemistry, 475, 14-21 (2015-01-03)
Embryo implantation requires a healthy embryo and a receptive uterus. In women, the inner lining of the uterus, the endometrium, remains in a hostile state and becomes receptive for embryo implantation for only a short period during each menstrual cycle....
Peng Ye et al.
Molecular and cellular biology, 34(18), 3421-3434 (2014-07-09)
The ubiquitin-proteasome pathway degrades ubiquitinated proteins to remove damaged or misfolded protein and thus plays an important role in the maintenance of many important cellular processes. Because the pathway is also crucial for tumor cell growth and survival, proteasome inhibition...
Diana Gaspar et al.
Biochimica et biophysica acta, 1853(2), 308-316 (2014-12-03)
Cancer remains a major cause of morbidity and mortality worldwide. Although progress has been made regarding chemotherapeutic agents, new therapies that combine increased selectivity and efficacy with low resistance are still needed. In the search for new anticancer agents, therapies...
Helene Blanchard et al.
Neurochemical research, 39(8), 1522-1532 (2014-06-13)
Calcium-independent phospholipase A2 group VIa (iPLA2β) preferentially releases docosahexaenoic acid (DHA) from the sn-2 position of phospholipids. Mutations of its gene, PLA2G6, are found in patients with several progressive motor disorders, including Parkinson disease. At 4 months, PLA2G6 knockout mice (iPLA2β(-/-))...
Elvis B Kidzeru et al.
AIDS (London, England), 28(10), 1421-1430 (2014-05-03)
In sub-Saharan Africa, HIV-exposed uninfected (HEU) infants have higher morbidity and mortality than HIV-unexposed infants. To evaluate whether immune dysfunction contributes to this vulnerability of HEU infants, we conducted a longitudinal, observational cohort study to assess T-cell immune responses to...
James M Amos-Landgraf et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(46), 16514-16519 (2014-11-05)
It recently has been recognized that men develop colonic adenomas and carcinomas at an earlier age and at a higher rate than women. In the Apc(Pirc/+) (Pirc) rat model of early colonic cancer, this sex susceptibility was recapitulated, with male...
Siobhain Mulrennan et al.
Scientific reports, 5, 8931-8931 (2015-03-11)
Cystic Fibrosis (CF) is often accompanied by diabetes leading to worsening lung function, the reason for which is unclear. The receptor for advanced-glycation-end-products (RAGE) regulates immune responses and inflammation and has been linked to diabetes and possibly CF. We performed...
Bingning Dong et al.
Nature communications, 6, 5944-5944 (2015-02-11)
Aberrant β-catenin activation contributes to a third or more of human hepatocellular carcinoma (HCC), but β-catenin activation alone is not sufficient to induce liver cancer in mice. Differentiated hepatocytes proliferate upon acute activation of either β-catenin or the nuclear xenobiotic...
Julian C Lui et al.
Pediatric research, 77(3), 406-415 (2014-12-19)
In juvenile mammals, the epiphyses of long bones grow by chondrogenesis within the articular cartilage. A better understanding of the molecular mechanisms that regulate the growth of articular cartilage may give insight into the antecedents of joint disease, such as...
A Paradowska-Gorycka et al.
Scandinavian journal of immunology, 80(4), 298-305 (2014-07-22)
Rheumatoid arthritis (RA) is one of the autoimmune diseases, where different polymorphisms in cytokine genes play a pathogenic role. Interleukin 27 (IL-27) is a novel pro-/anti-inflammatory cytokine, an excellent candidate for chronic inflammatory disease studies. The aim of the study...
Clara Sciorati et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(3), 809-822 (2014-12-17)
Muscle regeneration is a hallmark of the idiopathic inflammatory myopathies (IIMs), a group of autoimmune disorders that are characterized by leukocyte infiltration and dysfunction of the skeletal muscle. Despite detailed studies describing the clinical and histopathologic features of IIMs, the...
Colm E Nestor et al.
Genome biology, 16, 11-11 (2015-02-05)
The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the...
Taesun Eom et al.
The Journal of cell biology, 207(2), 237-252 (2014-10-22)
In neurons, translational regulation of gene expression has been implicated in the activity-dependent management of synapto-dendritic protein repertoires. However, the fundamentals of stimulus-modulated translational control in neurons remain poorly understood. Here we describe a mechanism in which regulatory brain cytoplasmic...
S Moradi et al.
The New Zealand dental journal, 110(4), 126-129 (2015-01-20)
A curvature leads to asymmetrical removal of root dentine, which results in an increase in the incidence of canal transportation. The aim of this study was to evaluate the effect of master apical file (MAF) size on the apical transportation...
Q Bao et al.
Targeted oncology, 9(3), 251-261 (2013-08-13)
Fibrosarcomas show a high incidence of recurrence and general resistance to apoptosis. Limiting tumor regrowth and increasing their sensitivity to chemotherapy and apoptosis represent key issues in developing more effective treatments of these tumors. Tissue inhibitor of metalloproteinase 1 (TIMP-1)...
Qian Guo et al.
Biomedical and environmental sciences : BES, 28(1), 25-35 (2015-01-09)
A PCR-reverse dot blot hybridization (RDBH) assay was developed for rapid detection of rpoB gene mutations in 'hot mutation region' of Mycobacterium tuberculosis (M. tuberculosis). 12 oligonucleotide probes based on the wild-type and mutant genotype rpoB sequences of M. tuberculosis...
Indu Upadhyaya et al.
Applied and environmental microbiology, 81(9), 2985-2994 (2015-02-25)
Salmonella enterica serovar Enteritidis is a major foodborne pathogen in the United States, causing gastroenteritis in humans, primarily through consumption of contaminated eggs. Chickens are the reservoir host of S. Enteritidis. In layer hens, S. Enteritidis colonizes the intestine and...
Lin Zhang et al.
PloS one, 10(4), e0123104-e0123104 (2015-04-11)
DYT1 dystonia is a heritable, early-onset generalized movement disorder caused by a GAG deletion (ΔGAG) in the DYT1 gene. Neuroimaging studies and studies using mouse models suggest that DYT1 dystonia is associated with dopamine imbalance. However, whether dopamine imbalance is...
Rosalyn R Ram et al.
Molecular and cellular biology, 34(12), 2350-2358 (2014-04-16)
The RASSF1A gene is one of the most frequently inactivated genes in over 30 different types of cancers (H. Donninger, M. D. Vos, and G. J. Clark, J. Cell Sci. 120:3163-3172, 2007, http://dx.doi.org/10.1242/jcs.010389). Despite the prevalence of RASSF1A silencing in...
Elisa Lucas et al.
Biochimica et biophysica acta, 1842(12 Pt A), 2448-2456 (2014-09-23)
G protein-coupled receptor kinase 2 (GRK2) has recently emerged as a negative modulator of insulin signaling. GRK2 downregulation improves insulin sensitivity and prevents systemic insulin resistance. Cardiac GRK2 levels are increased in human heart failure, while genetically inhibiting GRK2 leads...
Hiroyoshi Hattori et al.
Cell cycle (Georgetown, Tex.), 13(16), 2572-2586 (2014-12-09)
The human DNA damage response (DDR) triggers profound changes in gene expression, whose nature and regulation remain uncertain. Although certain micro-(mi)RNA species including miR34, miR-18, miR-16 and miR-143 have been implicated in the DDR, there is as yet no comprehensive...
Christopher B Toomey et al.
Toxicological sciences : an official journal of the Society of Toxicology, 142(2), 339-349 (2014-09-23)
Susceptibility and resistance to systemic autoimmunity are genetically regulated. This is particularly true for murine mercury-induced autoimmunity (mHgIA) where DBA/2J mice are considered resistant to disease including polyclonal B cell activation, autoantibody responses, and immune complex deposits. To identify possible...
Ping Xiang et al.
Journal of neuroimmunology, 279, 50-63 (2015-02-12)
In the present study, we investigated the mechanism of activation of NG2 expressing cells. Application of microglial inhibitors not only attenuated morphological changes but also significantly retarded increase in the number of NG2 expressing cells. Intracerebral injection of TGF-β1 led...
Yong Wang et al.
Molecular and cellular endocrinology, 406, 68-77 (2015-03-05)
Nerve growth factor (NGF) is known to play key roles in ovarian follicular development, such as the assembly of early follicles and follicular ovulation through its high-affinity receptor, tyrosine kinase receptor A (trkA). Herein, the molecular mechanism controlling NGF-induced granulosa...
页码 1 来自 139
页码 1 来自 139