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Wancheng Liu et al.
Cellular & molecular immunology, 18(12), 2660-2672 (2021-11-17)
The tumor microenvironment (TME), including infiltrated immune cells, is known to play an important role in tumor growth; however, the mechanisms underlying tumor immunogenicity have not been fully elucidated. Here, we discovered an unexpected role for the transcription factor SIX1
Uta Gehlsen et al.
International journal of molecular sciences, 22(12) (2021-07-03)
Ocular graft-versus-host disease (oGVHD) is a fast progressing, autoimmunological disease following hematopoietic stem cell transplantation, leading to severe inflammation of the eye and destruction of the lacrimal functional unit with consecutive sight-threatening consequences. The therapeutic "window of opportunity" is narrow
Vanda Póvoa et al.
Nature communications, 12(1), 1156-1156 (2021-02-21)
Cancer immunoediting is a dynamic process of crosstalk between tumor cells and the immune system. Herein, we explore the fast zebrafish xenograft model to investigate the innate immune contribution to this process. Using multiple breast and colorectal cancer cell lines
Nishant Mehta et al.
Scientific reports, 10(1), 15171-15171 (2020-09-18)
V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint that maintains peripheral T cell quiescence and inhibits anti-tumor immune responses. VISTA functions by dampening the interaction between myeloid cells and T cells, orthogonal to PD-1 and
Djalma S Lima-Junior et al.
Cell, 184(14), 3794-3811 (2021-06-25)
The microbiota plays a fundamental role in regulating host immunity. However, the processes involved in the initiation and regulation of immunity to the microbiota remain largely unknown. Here, we show that the skin microbiota promotes the discrete expression of defined
Risheng Ye et al.
eLife, 3, doi:10-doi:10 (2014-10-24)
As an adipokine in circulation, adiponectin has been extensively studied for its beneficial metabolic effects. While many important functions have been attributed to adiponectin under high-fat diet conditions, little is known about its essential role under regular chow. Employing a
Herlon Victor Rodrigues Silva et al.
Biopreservation and biobanking, 18(5), 415-424 (2020-08-12)
Anhydrous preservation is a promising approach for storage of living biomaterials at nonfreezing temperatures. Using the domestic cat model, the objectives of this study were to characterize changes in histology, DNA integrity, and viability of testicular tissues from adult versus
Martyna Okuniewska et al.
Cell reports, 36(2), 109368-109368 (2021-07-15)
T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph nodes (LNs) into lymph, while endothelial S1PR1 expression regulates vascular permeability. Drugs targeting S1PR1 treat autoimmune disease by trapping pathogenic T cells within LNs, but they
Matheus H W Crommentuijn et al.
Journal for immunotherapy of cancer, 8(1) (2020-04-19)
Glioblastoma (GBM) is the most common and deadliest form of brain cancer in adults. Standard treatment, consisting of surgery and radiochemotherapy, only provides a modest survival benefit and is incapable of combating infiltrating GBM cells in other parts of the
Noémie Hamilton et al.
Glia, 68(7), 1531-1545 (2020-03-27)
The contribution of microglia in neurological disorders is emerging as a leading disease driver rather than a consequence of pathology. RNAseT2-deficient leukoencephalopathy is a severe childhood white matter disorder affecting patients in their first year of life and mimicking a
Adrian Filiberti et al.
Investigative ophthalmology & visual science, 61(10), 24-24 (2020-08-14)
Corneal opacity and neovascularization (NV) are often described as outcomes of severe herpes simplex virus type 1 (HSV-1) infection. The current study investigated the role of colony-stimulating factor 1 receptor (CSF1R)+ cells and soluble factors in the progression of HSV-1-induced
Patrice Zeis et al.
Immunity, 53(4), 775-792 (2020-10-02)
Innate lymphoid cells (ILCs) are generated early during ontogeny and persist predominantly as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within tissues. We generated a single cell atlas of lung ILC2s and found that Il18r1+ ILCs
Christine M Kusminski et al.
Diabetes, 65(6), 1534-1555 (2016-02-21)
Mitochondrial metabolism plays an integral role in glucose-stimulated insulin secretion (GSIS) in β-cells. In addition, the diabetogenic role of glucagon released from α-cells plays a major role in the etiology of both type 1 and type 2 diabetes because unopposed
Esmé Ti van der Gracht et al.
Journal for immunotherapy of cancer, 8(2) (2020-12-10)
Adenoviral vectors emerged as important platforms for cancer immunotherapy. Vaccination with adenoviral vectors is promising in this respect, however, their specific mechanisms of action are not fully understood. Here, we assessed the development and maintenance of vaccine-induced tumor-specific CD8+ T
Dulguun Amgalan et al.
Nature cancer, 1(3), 315-328 (2020-08-11)
Doxorubicin remains an essential component of many cancer regimens, but its use is limited by lethal cardiomyopathy, which has been difficult to target, owing to pleiotropic mechanisms leading to apoptotic and necrotic cardiac cell death. Here we show that BAX
Jyoti Pant et al.
PLoS pathogens, 17(9), e1008768-e1008768 (2021-09-25)
Trypanosome Lytic Factor (TLF) is a primate-specific high-density lipoprotein (HDL) complex that, through the cation channel-forming protein apolipoprotein L-1 (APOL1), provides innate immunity to select kinetoplastid parasites. The immunoprotective effects of TLF have been extensively investigated in the context of
Dongdong Zhu et al.
American journal of translational research, 13(3), 1155-1169 (2021-04-13)
Acute kidney injury (AKI) is a common clinical implication with increased tissue damage, uncontrolled immune responses, and risk of mortality, in which ischemia-reperfusion injury (IRI) is one of the leading causes. As critical role for metabolic remodeling in inflammation, Irg1-itaconate
Erik J Zmuda et al.
Journal of visualized experiments : JoVE, (50)(50), doi:10-doi:10 (2011-04-29)
Since the early pioneering work of Ballinger and Reckard demonstrating that transplantation of islets of Langerhans into diabetic rodents could normalize their blood glucose levels, islet transplantation has been proposed to be a potential treatment for type 1 diabetes. More
Federica La Russa et al.
The Journal of investigative dermatology, 139(9), 1936-1945 (2019-04-12)
Increasing evidence suggests that nerve fibers responding to noxious stimuli (nociceptors) modulate immunity in a variety of tissues, including the skin. Yet, the role of nociceptors in regulating sterile cutaneous inflammation remains unexplored. To address this question, we have developed
Anna Śledzińska et al.
Immunity, 52(1), 151-166 (2020-01-12)
In addition to helper and regulatory potential, CD4+ T cells also acquire cytotoxic activity marked by granzyme B (GzmB) expression and the ability to promote rejection of established tumors. Here, we examined the molecular and cellular mechanisms underpinning the differentiation of
Kavaljit H Chhabra et al.
American journal of physiology. Endocrinology and metabolism, 304(8), E874-E884 (2013-03-07)
An overactive renin-angiotensin system (RAS) is known to contribute to type 2 diabetes mellitus (T2DM). Although ACE2 overexpression has been shown to be protective against the overactive RAS, a role for pancreatic ACE2, particularly in the islets of Langerhans, in
Trung H M Pham et al.
Cell host & microbe, 27(1), 54-67 (2019-12-31)
Many intracellular bacteria can establish chronic infection and persist in tissues within granulomas composed of macrophages. Granuloma macrophages exhibit heterogeneous polarization states, or phenotypes, that may be functionally distinct. Here, we elucidate a host-pathogen interaction that controls granuloma macrophage polarization
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