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Håkan C Steen et al.
Journal of cell science, 129(22), 4190-4199 (2016-11-02)
Serine phosphorylation of STAT proteins is an important post-translational modification event that, in addition to tyrosine phosphorylation, is required for strong transcriptional activity. However, we recently showed that phosphorylation of STAT2 on S287 induced by type I interferons (IFN-α and
M Mutocheluh et al.
The Journal of general virology, 92(Pt 10), 2394-2398 (2011-06-24)
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition of interferon-response element signalling following type I interferon (IFN) induction. Western blot and electrophoretic mobility-shift assays identified the interferon-stimulated gene
Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade.
Lam, E; Stein, S; Falck-Pedersen, E
Journal of virology null
Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2.
Testoni, B; Vollenkle, C; Guerrieri, F; Gerbal-Chaloin, S; Blandino, G; Levrero, M
The Journal of Biological Chemistry null
Alessandra Aiello et al.
Viruses, 14(1) (2022-01-23)
Plasmacytoid dendritic cells (pDCs) are a unique dendritic cell subset specialized in type I interferon production, whose role in Human Immunodeficiency Virus (HIV) infection and pathogenesis is complex and not yet well defined. Considering the crucial role of the accessory
Xiaoyan Guo et al.
BMC molecular and cell biology, 21(1), 6-6 (2020-02-20)
Interferon-alpha (IFNα) is a first-line treatment option for chronic hepatitis B virus (HBV) infection, but the severe systemic side-effects limited its clinical application. Interferon-lambda (IFNλ) with comparable antiviral activity and less toxic side-effects is thought to be a good alternative
Daipayan Banerjee et al.
Nature communications, 12(1), 6207-6207 (2021-10-29)
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), produced by cyclic GMP-AMP synthase (cGAS), stimulates the production of type I interferons (IFN). Here we show that cGAMP activates DNA damage response (DDR) signaling independently of its canonical IFN pathways. Loss of cGAS dampens
Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction.
Ramaswamy, M; Shi, L; Varga, SM; Barik, S; Behlke, MA; Look, DC
Virology null
The type I interferon signaling pathway is a target for glucocorticoid inhibition.
Flammer, JR; Dobrovolna, J; Kennedy, MA; Chinenov, Y; Glass, CK; Ivashkiv, LB; Rogatsky, I
Molecular and cellular biology null
B Testoni et al.
Oncogene, 30(23), 2670-2678 (2011-03-15)
The DNp73 proteins act as trans-repressors of p53 and p73-dependent transcription and exert both anti-apoptotic activity and pro-proliferative activity. DNp73s are frequently up-regulated in a variety of human cancers, including human hepatocellular carcinomas (HCCs). Increased levels of DNp73 proteins confer
Jennifer H Stuart et al.
PLoS pathogens, 12(12), e1005955-e1005955 (2016-12-03)
The type I interferon (IFN) response is a crucial innate immune signalling pathway required for defense against viral infection. Accordingly, the great majority of mammalian viruses possess means to inhibit this important host immune response. Here we show that vaccinia
M G Mathieu et al.
Cell death & disease, 5, e1061-e1061 (2014-02-15)
The tumour suppressor PML (promyelocytic leukaemia protein) regulates several cellular pathways involving cell growth, apoptosis, differentiation and senescence. PML also has an important role in the regulation of stem cell proliferation and differentiation. Here, we show the involvement of the
Iryna Kolosenko et al.
International journal of cancer, 136(4), E51-E61 (2014-08-27)
The mechanism of multicellular drug resistance, defined as the reduced efficacy of chemotherapeutic drugs in solid tumors is incompletely understood. Here we report that colon carcinoma cells cultured as 3D microtissues (spheroids) display dramatic increases in the expression of a
Shinichi Kadota et al.
Journal of cell science, 124(Pt 6), 892-899 (2011-02-18)
Type I interferon (IFN) plays a crucial role in establishing the cellular antiviral state by inducing transcription of IFN-stimulated genes (ISGs). Generally, histone acetyltransferases (HATs) are positive regulators of transcription, but histone deacetylase (HDAC) activity is essential for transcriptional induction
West Nile virus inhibits the signal transduction pathway of alpha interferon.
Guo, JT; Hayashi, J; Seeger, C
Journal of virology null
Nagaraj Kerur et al.
Nature medicine, 24(1), 50-61 (2017-11-28)
Geographic atrophy is a blinding form of age-related macular degeneration characterized by retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency, resultant accumulation of endogenous Alu-retroelement RNA, and NLRP3-inflammasome activation. How the inflammasome is activated in this untreatable
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
Kaoru Takeuchi, Shin-ich Kadota, Makoto Takeda, Naoko Miyajima, Kyosuke Nagata
Febs Letters null
Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses.
Steen, HC; Nogusa, S; Thapa, RJ; Basagoudanavar, SH; Gill, AL; Merali, S; Barrero et al.
The Journal of Biological Chemistry null
Anna Piaszyk-Borychowska et al.
Frontiers in immunology, 10, 1253-1253 (2019-06-25)
Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by atherosclerotic lesion formation. Vascular Smooth Muscle Cells (VSMC), macrophages (MΦ), and dendritic cells (DC) play a crucial role in vascular inflammation and atherosclerosis. Interferon (IFN)α, IFNγ, and Toll-like
Targeting of the Sendai virus C protein to the plasma membrane via a peptide-only membrane anchor.
Marq, JB; Brini, A; Kolakofsky, D; Garcin, D
Journal of virology null
Giuseppe Pisanelli et al.
Virus research, 213, 11-22 (2015-11-08)
La Piedad Michoacán Mexico Virus (LPMV) is a member of the Rubulavirus genus within the Paramyxoviridae family. LPMV is the etiologic agent of "blue eye disease", causing a significant disease burden in swine in Mexico with long-term implications for the
The V protein of mumps virus plays a critical role in pathogenesis.
Xu, P; Luthra, P; Li, Z; Fuentes, S; D'Andrea, JA; Wu, J; Rubin, S; Rota, PA; He, B
Journal of virology null
The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells.
Geiger, TR; Martin, JM
Journal of virology null
Katarzyna Blaszczyk et al.
The Biochemical journal, 466(3), 511-524 (2015-01-08)
Evidence is accumulating for the existence of a signal transducer and activator of transcription 2 (STAT2)/interferon regulatory factor 9 (IRF9)-dependent, STAT1-independent interferon alpha (IFNα) signalling pathway. However, no detailed insight exists into the genome-wide transcriptional regulation and the biological implications
Ivana Wiesauer et al.
Molecular and cellular biology, 35(4), 716-727 (2014-12-17)
Interferons regulate immunity by inducing DNA binding of the transcription factor STAT1 through Y701 phosphorylation. Transcription by STAT1 needs to be restricted to minimize the adverse effects of prolonged immune responses. It remains unclear how STAT1 inactivation is regulated such
Murali Ramaswamy et al.
American journal of respiratory cell and molecular biology, 30(6), 893-900 (2004-01-15)
Respiratory viruses often express mechanisms to resist host antiviral systems, but the biochemical basis for evasion of interferon effects by respiratory syncytial virus (RSV) is poorly defined. In this study, we identified RSV effects on interferon (IFN)-dependent signal transduction and
Characterization of the amino acid residues of sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation.
Kato, A; Cortese-Grogan, C; Moyer, SA; Sugahara, F; Sakaguchi, T; Kubota, T; Otsuki et al.
Journal of virology null
ALL-associated JAK1 mutations confer hypersensitivity to the antiproliferative effect of type I interferon.
Hornakova, T; Chiaretti, S; Lemaire, MM; Foa, R; Ben Abdelali, R; Asnafi, V; Tartaglia et al.
Blood null
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