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显示 1-30 共 30 条结果 关于 "124-20-9" 范围 论文
Vicki L J Whitehall et al.
International journal of cancer, 131(4), 813-820 (2011-09-21)
Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic association of PIK3CA mutation with KRAS mutation has been suggested to increase AKT signaling and resistance to antiepidermal growth factor
Patiyan Andersson et al.
European journal of cancer (Oxford, England : 1990), 42(16), 2833-2837 (2006-10-03)
We study the CAG repeat region in exon 1 of the androgen receptor (AR) and the TaqI polymorphism in exon 9 of the vitamin D receptor (VDR) and the association with prostate cancer. 137 incidentally discovered, histologically verified prostate cancers
Vanessa Moraes Bezerra et al.
Autonomic neuroscience : basic & clinical, 162(1-2), 48-53 (2011-05-04)
In this study we assessed the role of Bezold-Jarisch reflex (BJR) in the regulation of blood pressure (BP) of malnourished (MN) and control rats (CN) with sino-aortic denervation (SAD). Fischer rats were fed diets containing either 6% (MN) or 15%
William B Clark et al.
Blood, 118(4), 1140-1144 (2011-06-02)
B-cell activating factor (BAFF) single nucleotide polymorphisms (SNPs) are associated with autoimmune diseases. Because patients with classic and overlap chronic GVHD (cGVHD) have features of autoimmune diseases, we studied the association of recipient and/or donor BAFF SNPs with the phenotype
H Kono et al.
The Tohoku journal of experimental medicine, 152(2), 133-137 (1987-06-01)
We measured maternal cortisol levels after the onset of labor. Blood from 82 primiparas and 48 multiparas were collected 124 times and 60 times, respectively. When duration of labor was within 3 hr, there were no differences in cortisol levels
Yuri Takano et al.
Journal of cardiology, 60(1), 18-22 (2012-03-23)
We have reported that α and β adrenergic blockers could protect against emotional stress-induced cardiac dysfunction. Azelnidipine is a unique calcium blocker which does not increase heart rate. The purpose of this study is to evaluate the effect of azelnidipine
Z Tiszlavicz et al.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 10(4), 483-490 (2010-08-20)
Bacterial translocation from the intestinal tract plays an important role in severe acute pancreatitis (AP). Human β-defensins are a family of antimicrobial peptides present at the mucosal surface. The aim of this study was to investigate the relevance of single
Abbas Agaimy et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(7), 995-1003 (2013-03-19)
The human insulin gene enhancer-binding protein islet-1 (ISL1) is a transcription factor involved in the differentiation of the neuroendocrine pancreatic cells. Recent studies identified ISL1 as a marker for pancreatic well-differentiated neuroendocrine neoplasms. However, little is known about ISL1 expression
W M Abbott et al.
The Journal of biological chemistry, 266(9), 5552-5557 (1991-03-25)
The soluble beta-galactoside-specific bovine lectin of subunit 14 kDa has been expressed in vitro by transcription and then translation in a rabbit reticulocyte lysate. The protein thus expressed shows the predicted binding to lactose coupled to Sepharose. Several mutants of
Dan Zhao et al.
Zhonghua fu chan ke za zhi, 44(2), 87-90 (2009-07-03)
To explore the role of H19 imprinting in etiology of pre-eclampsia. Placentas of 24 women with pre-eclampsia (3 with mild pre-eclampsia and 21 with severe pre-eclampsia) and 50 healthy pregnant women at full term (control) were collected during selected cesarean
Naohide Oue et al.
Annals of surgical oncology, 19(6), 1902-1910 (2011-12-29)
Patients diagnosed with stage II and III esophageal squamous cell carcinoma (ESCC) have variable prognosis. This group would benefit greatly from the discovery of prognostic markers that are capable of identifying individuals for whom adjuvant treatment would be advantageous. The
Peyman Björklund et al.
Molecular cancer, 7, 53-53 (2008-06-11)
Aberrant accumulation of beta-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of beta-catenin in parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). In CTNNB1 exon 3, we detected a stabilizing mutation (S37A) in
Ravi Ramani et al.
Clinical and translational science, 4(1), 24-31 (2011-02-26)
Adenoviral-mediated (AdV-T2) overexpression of TIMP-2 would blunt ventricular remodeling and improve survival in a murine model of chronic ischemic injury. Male mice (n = 124) aged 10-14 weeks underwent either (1) left coronary artery ligation to induce myocardial infarction (MI
M J Gibson et al.
Animal reproduction science, 214, 106312-106312 (2020-02-24)
There is an epidemic in New Zealand of infectious bovine anaemia associated with Theileria orientalis Ikeda type, an obligate intracellular protozoan parasite. To establish whether T. orientalis Ikeda type infection adversely affects fertility of bulls used for natural mating, a
Lacy M Alexander et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(2), R164-R169 (2012-11-30)
Localized exogenous R-tetrahydrobiopterin (R-BH(4)) corrects the deficit in local heat-induced vasodilation (VD) in hypercholesterolemic (HC) human skin through one of two plausible mechanisms: by serving as an essential cofactor to stabilizing endothelial nitric oxide (NO) synthase (eNOS) or through generalized
Wendy De Roock et al.
The Lancet. Oncology, 11(8), 753-762 (2010-07-14)
Following the discovery that mutant KRAS is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodies, the tumours of patients with metastatic colorectal cancer are now profiled for seven KRAS mutations before receiving cetuximab or panitumumab. However, most patients
J Rosemary et al.
European journal of clinical pharmacology, 61(1), 19-23 (2005-01-22)
To investigate the relationship between CYP2C19 genotypes and the hydroxylation index (HI) of omeprazole in the South Indian population. Healthy unrelated South Indian subjects (n=300) were separated into three groups based on their CYP2C19 genotypes. They were administered a single
Jörg Johannes et al.
Journal of bacteriology, 190(19), 6493-6500 (2008-07-29)
p-Cresol methylhydroxylases (PCMH) from aerobic and facultatively anaerobic bacteria are soluble, periplasmic flavocytochromes that catalyze the first step in biological p-cresol degradation, the hydroxylation of the substrate with water. Recent results suggested that p-cresol degradation in the strictly anaerobic Geobacter
Amit Arora et al.
BMC developmental biology, 10, 1-1 (2010-01-08)
MicroRNAs (miRNAs) are small RNA molecules (~22 nucleotides) which have been shown to play an important role both in development and in maintenance of adult tissue. Conditional inactivation of miRNAs in the eye causes loss of visual function and progressive
C A Berg et al.
Clinical endocrinology, 70(3), 439-445 (2008-12-11)
At diagnosis, approximately 50% of adults with severe GH deficiency (GHD) have an IGF-I within the reference range. It is unclear whether in such patients serum IGF-I levels are regulated by factors other than GH. We performed a double-blind, randomized
Yu Chieh Su et al.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 40(1), 62-67 (2007-03-03)
The objective of this study was to document the clinical experience of cefpirome use in the treatment of febrile neutropenia in everyday medical practice. This was an open, non-controlled multicenter study. Patients with fever and neutropenia were started on cefpirome
Scott W Powers et al.
JAMA, 310(24), 2622-2630 (2013-12-26)
Early, safe, effective, and durable evidence-based interventions for children and adolescents with chronic migraine do not exist. To determine the benefits of cognitive behavioral therapy (CBT) when combined with amitriptyline vs headache education plus amitriptyline. A randomized clinical trial of
D A Fisher et al.
Biochemical and biophysical research communications, 246(3), 570-577 (1998-06-10)
As part of our efforts to understand the regulation of intracellular cAMP and to generate new targets for pharmacological intervention, we have cloned and characterized the first isozyme in a new family of cyclic nucleotide phosphodiesterases, PDE8A. PDE8A is most
I J Chopra et al.
Thyroid : official journal of the American Thyroid Association, 6(4), 255-259 (1996-08-01)
We have devised a practical, sensitive, and reliable assay for measurement of free T3 concentration in serum. The assay employs a convenient and disposable plastic equilibrium dialysis cell and a buffer that resembles the in vivo biochemical environment (Nelson JC
Suresh Hedau et al.
Breast cancer research and treatment, 88(2), 177-186 (2004-11-27)
Mutations in breast cancer susceptibility genes, BRCA1 and BRCA2 account for more than 80% of hereditary breast and ovarian cancers. p53 tumor suppressor gene that controls cellular growth and differentiation is also known to be mutated in more than 50%
Susan K Fellner et al.
American journal of physiology. Renal physiology, 289(5), F1012-F1019 (2005-06-09)
In afferent arteriolar vascular smooth muscle cells, ANG II induces a rise in cytosolic Ca(2+) ([Ca(2+)](i)) via inositol trisphosphate receptor (IP(3)R) stimulation and by activation of the adenine diphosphate ribose (ADPR) cyclase to form cyclic ADPR, which sensitizes the ryanodine
Atsushi Masamune et al.
Gastroenterology, 158(6), 1626-1641 (2020-01-14)
Changes in pancreatic calcium levels affect secretion and might be involved in development of chronic pancreatitis (CP). We investigated the association of CP with the transient receptor potential cation channel subfamily V member 6 gene (TRPV6), which encodes a Ca2+-selective
M Pestana et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 16 Suppl 1, 53-59 (2001-05-23)
The present report addresses the status of the renal dopaminergic system activity in patients afflicted with different renal disorders and in the remnant kidney of uninephrectomized (UNX) rats, based on the urinary excretion of L-DOPA, dopamine and amine metabolites. In
Juan W Valle et al.
The Lancet. Oncology, 16(8), 967-978 (2015-07-17)
Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for patients with advanced biliary tract cancer; expression of VEGF and its receptors is associated with adverse outcomes. We aimed to assess the effect of the addition of cediranib (an oral
Victor Kande Betu Ku Mesu et al.
Lancet (London, England), 391(10116), 144-154 (2017-11-09)
Few therapeutic options are available to treat the late-stage of human African trypanosomiasis, a neglected tropical disease, caused by Trypanosoma brucei gambiense (g-HAT). The firstline treatment is a combination therapy of oral nifurtimox and intravenous eflornithine that needs to be