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R Volchenkov et al.
Scandinavian journal of immunology, 77(4), 246-254 (2013-02-28)
Dendritic cells (DC) are professional antigen-presenting cells that are capable of both activating immune responses and inducing tolerance. Several studies have revealed efficiency of therapeutic vaccination with tolerogenic DC (tolDC) in inhibition of experimental autoimmunity. The purpose of this study...
Grazia Chiellini et al.
Bioorganic & medicinal chemistry, 16(18), 8563-8573 (2008-08-30)
In a continuing effort to explore the 2-methylene-1alpha-hydroxy-19-norvitamin D(3) class of pharmacologically important vitamin D compounds, two novel 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones, GC-3 and HLV, were synthesized and biologically tested. Based on reports of similarly structured molecules, it was hypothesized that these...
Weiwei Sun et al.
American journal of physiology. Endocrinology and metabolism, 308(1), E51-E62 (2014-11-06)
We used mice with targeted deletion of 25-hydroxyvitamin D-1 α-hydroxylase [1α(OH)ase(-/-)] to investigate whether 1,25(OH)2D3 deficiency results in male infertility mediated by 1,25(OH)2D3 or extracellular calcium and phosphorus. Male 1α(OH)ase(-/-) and their wild-type littermates fed either a normal diet or...
Gabriela Bomfim Ferreira et al.
The Journal of steroid biochemistry and molecular biology, 136, 160-165 (2012-10-27)
The biologically active form of vitamin D, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), presents pronounced immunomodulatory effects, mainly mediated through its actions on different immune cells such as dendritic cells (DC) and T lymphocytes. Because of the high concentrations needed to obtain immune...
Physiology of the Gastrointestinal Tract (2012)
Evelyne Van Etten et al.
Journal of cellular biochemistry, 88(2), 223-226 (2003-01-10)
The active form of vitamin D(3), 1,25(OH)(2)D(3), is known, besides its classical effects on calcium and bone, for its pronounced immunomodulatory effects that are exerted both on the antigen-presenting cell level as well as directly on the T lymphocyte level....
R S Mason et al.
Annals of internal medicine, 100(1), 59-61 (1984-01-01)
Recent studies suggest that hypercalcemia of sarcoidosis is due to high blood concentrations of calcitriol and that this compound may be synthesized at an extra-renal site. We report that sarcoid lymph node homogenate metabolized calcifediol to a substance indistinguishable from...
Agnes E Nystad et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(12), 1178-1186 (2014-05-28)
Vitamin D supplementation is increasingly recommended to patients with multiple sclerosis (MS). To study the effect of high-dose vitamin D on remyelination, female C57Bl/6 mice were demyelinated with dietary 0.2% cuprizone for 7 weeks. The mice received intraperitoneal injections of...
Raul A Chavez Valencia et al.
The Journal of steroid biochemistry and molecular biology, 141, 144-149 (2014-02-15)
It is well-established that vitamin D impacts gene regulation via vitamin D response elements (VDREs) across the genome. Recent evidence, primarily at a locus-specific level, suggests that alterations to DNA methylation may also be a relevant mechanism through which vitamin...
Maria J Ramalho et al.
Beilstein journal of nanotechnology, 6, 1306-1318 (2015-07-23)
Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on human pancreatic cell lines, S2-013...
Lisa Asano et al.
FEBS letters, 587(7), 957-963 (2013-03-07)
Non-secosteroidal ligands for vitamin D receptor (VDR) have been developed for the agonist with non-calcemic profiles. Here, we provide the structural mechanism of VDR agonism by novel non-secosteroidal ligands. All ligands had the similar efficacy, while two had the higher...
Myfanwy Geyer et al.
Pediatrics, 134(6), e1720-e1726 (2014-11-19)
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome is a monogenic disorder associated with autoimmune destruction of both endocrine and nonendocrine tissues. The classic triad includes candidiasis, hypoparathyroidism, and Addison disease. Up to 25% of patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy...
Kishore R Rollakanti et al.
Photochemistry and photobiology, 91(6), 1469-1478 (2015-08-01)
Better noninvasive techniques are needed to monitor protoporphyrin IX (PpIX) levels before and during photodynamic therapy (PDT) of squamous cell carcinoma (SCC) of the skin. Our aim was to evaluate (1) multispectral fluorescent imaging of ultraviolet light (UV)-induced cancer and...
Ming Kong et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(9), G883-G893 (2014-09-13)
Vitamin D deficiency (VDD) or insufficiency is recognized for its association with nonalcoholic steatohepatitis (NASH), whereas the underlying mechanism remains unknown. Using animal models, we found that vitamin D deficiency promoted the high-fat diet (HFD)-initiated simple steatosis into typical NASH...
Michael J Tidman
The Practitioner, 257(1757), 27-30 (2013-03-09)
Psoriasis is a heterogeneous inflammatory disorder that targets the skin and joints. It affects 1.3-2% of the population. The diagnosis of plaque psoriasis is usually straightforward, a helpful diagnostic clue is the tendency for silver scales to appear after gentle...
Association of oral calcitriol with improved survival in non-dialysed and dialysed patients with CKD.
Armando L Negri
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 24(2), 341-344 (2008-11-11)
Re: Persistence of 1,25D-induced hypercalciuria in alendronate treated genetic hypercalciuric stone-forming rats fed a low calcium diet.
Dean G Assimos
The Journal of urology, 192(2), 615-615 (2014-07-19)
Richard T Piszczatowski et al.
Journal of cellular physiology, 230(11), 2634-2639 (2015-04-23)
Connective Tissue Growth Factor (CCN2/CTGF) and Nephroblastoma Overexpressed (CCN3/NOV) execute key functions within the hematopoietic compartment. Both are abundant in the bone marrow stroma, which is a niche for hematopoiesis and supports marrow function. Roles for 1,25-dihydroxyvitamin D3 (calcitriol) and...
Moira Cheung et al.
The Journal of clinical endocrinology and metabolism, 98(5), E954-E961 (2013-03-28)
X-linked hypophosphatemic rickets is caused by mutations in PHEX. Even though the disease is characterized by disordered skeletal mineralization, detailed bone densitometric studies are lacking. The aim of the study was to assess volumetric bone mineral density (vBMD) in X-linked...
Yunzi Chen et al.
The Journal of biological chemistry, 288(27), 19450-19458 (2013-05-15)
1,25-Dihydroxyvitamin D (1,25(OH)2D3) is known to suppress NF-κB activity, but the underlying mechanism remains poorly understood. Here we show that the vitamin D receptor (VDR) physically interacts with IκB kinase β (IKKβ) to block NF-κB activation. 1,25(OH)2D3 rapidly attenuates TNFα-induced...
Dimitrios T Papadimitriou et al.
Journal of diabetes, 5(3), 344-348 (2013-01-11)
Based on recent knowledge of the possible involvement of 1,25-dihydroxyvitamin D in the pathogenesis of type 1 diabetes (T1D) and the results of its administration in animal models, we conducted a clinical trial by treating high-risk children, positive for T1D...
Zhaoke Wu et al.
Scandinavian cardiovascular journal : SCJ, 50(1), 9-16 (2015-10-07)
Low vitamin D status has been shown to be associated with coronary artery disease. We planned to research the effects of vitamin D3 supplementation on the severity of coronary artery disease. We investigated the effect of 0.5 μg vitamin D3...
Tiago L Moda et al.
Bioorganic & medicinal chemistry, 15(24), 7738-7745 (2007-09-18)
A drug intended for use in humans should have an ideal balance of pharmacokinetics and safety, as well as potency and selectivity. Unfavorable pharmacokinetics can negatively affect the clinical development of many otherwise promising drug candidates. A variety of in...
R Sigüeiro et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt A, 204-206 (2013-11-06)
An efficient convergent synthesis of nonadeuterated 1α,25-dihydroxyvitamin D2 (1) by Pd(0)-catalyzed coupling between the boronate ester (upper fragment) and the enol triflate (A-ring fragment) is described. This article is part of a Special Issue entitled '16th Vitamin D Workshop'.
Qingsong Wang et al.
The Journal of biological chemistry, 289(17), 11681-11694 (2014-03-13)
Inadequate vitamin D status has been linked to increased risk of type 2 diabetes and cardiovascular disease. Inducible cyclooxygenase (COX) isoform COX-2 has been involved in the pathogenesis of such chronic inflammatory diseases. We found that the active form of...
Roger Bouillon et al.
Pediatric endocrinology reviews : PER, 10 Suppl 2, 354-366 (2013-07-19)
Even one century after its discovery, there are still many gaps in the understanding of the vitamin D endocrine system. Inactivation of the vitamin D receptor (VDR) or the enzymes metabolizing its ligand (especially Cyp27bl) in mice has clearly demonstrated...
Reply: To PMID 23957979.
Hoon-Soo Kim et al.
Journal of the American Academy of Dermatology, 70(4), 794-794 (2014-03-19)
Yueh-Ting Lee et al.
Nutrients, 5(4), 1336-1348 (2013-04-23)
Uremic hyperparathyroidism (UHPT) has been shown to contribute to the development and progression of chronic kidney disease-mineral bone disorder. UHPT is frequently observed in chronic dialysis patients, and patients with UHPT are associated with increased risk of all-cause and cardiovascular...
1, 25-dihydroxyvitamin D3 increases the transplantation success of human muscle precursor cells in SCID mice
Stephan L, et al.
Cell Transplantation, 16(4), 391-402 (2007)
N Carrillo-López et al.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 29(2), 103-108 (2009-04-28)
The mechanism of regulation of Parathyroid hormone (PTH) is complex, and diverse factors are involved: the fundamental ones are calcium, calcitriol and phosphorus. Calcium and calcitriol's mechanism of action takes place through its specific receptors, the calcium-sensing receptor (CaR) and...
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