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Myong-Ho Jeong et al.
Nature communications, 5, 5455-5455 (2014-11-20)
Canonical Wnt signalling regulates expansion of neural progenitors and functions as a dorsalizing signal in the developing forebrain. In contrast, the multifunctional co-receptor Cdo promotes neuronal differentiation and is important for the function of the ventralizing signal, Shh. Here we
Verónica Uribe et al.
Development (Cambridge, England), 141(21), 4168-4181 (2014-10-23)
Arid3b, a member of the conserved ARID family of transcription factors, is essential for mouse embryonic development but its precise roles are poorly understood. Here, we show that Arid3b is expressed in the myocardium of the tubular heart and in
Yiji Cheng et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(3), 1163-1174 (2015-06-27)
Liver progenitor cells (LPCs) are bipotent stem cells existing in the adult liver, which could be activated upon massive liver injury and contribute to liver regeneration. However, mechanisms of maintenance of LPC functionality remain poorly understood. Previous studies found that
Q Li et al.
Cancer gene therapy, 22(5), 227-237 (2015-04-04)
An increasing number of studies indicate that during development, endothelial and hematopoietic cells derive from common progenitors named hemangioblasts that have important roles in the pathogenesis. This is particularly true in chronic myeloid leukemia (CML). Here, we isolated fetal liver
Matteo Centola et al.
Tissue engineering. Part C, Methods, 21(4), 394-403 (2014-09-17)
Enzymatic isolation of chondrocytes from a cartilage biopsy is the first step to establish in vitro models of chondrogenesis or to generate cell-based grafts for cartilage repair. Such process is based on manually operated procedures and typically results in yields
Mona Navaei-Nigjeh et al.
Journal of biomedical materials research. Part A, 102(8), 2533-2543 (2013-08-22)
Nerve tissue engineering (NTE) is one of the most promising methods to restore central nerve systems in human health care. Three-dimensional (3D) distribution and growth of cells within the porous scaffold composed of nanofibers are of clinical significance for NTE.
Sharla M Birch et al.
Alcohol (Fayetteville, N.Y.), 49(7), 675-689 (2015-10-27)
Identification of facial dysmorphology is essential for the diagnosis of fetal alcohol syndrome (FAS); however, most children with fetal alcohol spectrum disorders (FASD) do not meet the dysmorphology criterion. Additional objective indicators are needed to help identify the broader spectrum
William A Banks et al.
Journal of neuroinflammation, 12, 223-223 (2015-11-27)
Disruption of the blood-brain barrier (BBB) occurs in many diseases and is often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well established as a cause of BBB disruption, but many mechanistic questions remain. We used lipopolysaccharide (LPS) to induce
Ming-Li Chou et al.
PloS one, 9(6), e99145-e99145 (2014-06-20)
Clinical-grade ex vivo expansion of corneal endothelial cells can increase the availability of corneal tissues for transplantation and treatment of corneal blindness. However, these cells have very limited proliferative capacity. Successful propagation has required so far to use very complex
Kai-Oliver Feldmann et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(27), 9697-9712 (2015-05-12)
Although a fairly large number of binary group 15/16 element cations have been reported, no example involving phosphorus in combination with a group 16 element has been synthesized and characterized to date. In this contribution is reported the synthesis and structural characterization
Tsz Kin Ng et al.
Scientific reports, 5, 16429-16429 (2015-11-10)
Retinal diseases are the leading causes of irreversible visual impairment and blindness in the developed countries. Human retina has limited regenerative power to replace cell loss. Stem cell replacement therapy has been proposed as a viable option. Previously, we have
Alexander de Oliveira El-Warrak et al.
The Canadian veterinary journal = La revue veterinaire canadienne, 53(12), 1285-1288 (2013-06-05)
This study compared vitamin A, vitamin E, selenium (Se), and L-lactate in blood and synovial fluid in 2 groups of 6 dogs; a control group (without OA) and an osteoarthritic group with spontaneous cranial cruciate ligament rupture and OA. Concentrations
Reyhaneh Rahnama et al.
Environmental monitoring and assessment, 186(7), 4209-4216 (2014-03-05)
The developed method is based on cold-induced aggregation microextraction of Se(IV) using the 1-butyl-3-methylimidazolium hexafluorophosphate ionic liquid as an extractant followed by spectrophotometry determination. The extraction of Se(IV) was performed in the presence of dithizone as the complexing agent. In
Tiebing Liu et al.
PloS one, 10(7), e0133622-e0133622 (2015-07-18)
The etiology and pathophysiology of schizophrenia remain obscure. This study explored the associations between schizophrenia risk and serum levels of 10 trace elements. A 1:1 matched case-control study was conducted and matched by age and sex. Blood samples were collected
Matthew Loxham et al.
Toxicological sciences : an official journal of the Society of Toxicology, 145(1), 98-107 (2015-02-13)
We have previously shown that underground railway particulate matter (PM) is rich in iron and other transition metals across coarse (PM10-2.5), fine (PM2.5), and quasi-ultrafine (PM0.18) fractions and is able to generate reactive oxygen species (ROS). However, there is little
Kim De Nolf et al.
Journal of the American Chemical Society, 137(7), 2495-2505 (2015-01-30)
We investigate the relation between the chain length of ligands used and the size of the nanocrystals formed in the hot injection synthesis. With two different CdSe nanocrystal syntheses, we consistently find that longer chain carboxylic acids result in smaller
Christopher S Williams et al.
Carcinogenesis, 36(7), 710-718 (2015-04-29)
The ERBB4 receptor tyrosine kinase promotes colonocyte survival. Herein, we tested whether ERBB4's antiapoptotic signaling promotes transformation and colorectal tumorigenesis. ERBB4 alterations in a The Cancer Genome Atlas colorectal cancer (CRC) data set stratified survival, and in a combined Moffitt
Jan Philipp Krüger et al.
Annals of biomedical engineering, 42(12), 2562-2576 (2014-08-30)
In cartilage regeneration, bio-activated implants are used in stem and progenitor cell-based microfracture cartilage repair procedures. Our aim was to analyze the chondrogenic potential of freeze-dried resorbable polymer-based polyglycolic acid (PGA) scaffolds bio-activated with transforming growth factor-β3 (TGFB3) on human
Philippe Collery et al.
Anticancer research, 34(4), 1679-1689 (2014-04-03)
We proposed a new water-soluble rhenium diseleno-ether compound (with one atom of Re and two atoms of Se) and investigated the uptake of Re into the nucleus of malignant cells in culture exposed to the compound for 48 h and
Fangfang Wang et al.
Journal of liposome research, 25(2), 89-100 (2014-06-25)
We reported the development of multifunctional liposomes as a dual-modality probe to facilitate targeted magnetic resonance and fluorescent imaging of bone metastasis from advanced cancer. Multifunctional liposomes consisted of liposomes as a carrier, hydrophobic CdSe QDs in phospholipid bilayer, hydrophilic
E K Radhakrishnan et al.
PloS one, 9(8), e104401-e104401 (2014-08-27)
We report mechanism-based evidence for the anticancer and chemopreventive efficacy of [6]-gingerol, the major active principle of the medicinal plant, Ginger (Zingiber officinale), in colon cancer cells. The compound was evaluated in two human colon cancer cell lines for its
Marta Puig et al.
Molecular cancer research : MCR, 13(1), 161-173 (2014-10-05)
The crucial role of tumor-associated fibroblasts (TAF) in cancer progression is now clear in non-small cell lung cancer (NSCLC). However, therapies against TAFs are limited due to a lack of understanding in the subtype-specific mechanisms underlying their accumulation. Here, the
Jun Lu et al.
Biochemical and biophysical research communications, 453(3), 405-410 (2014-10-01)
The direct conversion of one cell type to another without an intermediate pluripotent stage is required for regenerative therapies. The ventral pancreas and liver share a common developmental origin. Recent studies have shown that hepatocytes could be induced to transdifferentiate
Zufei Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(6), 836-842 (2015-03-25)
In pregnant women, CYP3A activity increases by 100% during the third trimester (T3). Due to logistical and ethical constraints, little is known about the magnitude of CYP3A induction during the first trimester (T1) and second trimester (T2). Our laboratory has
Sachin Jhawar et al.
PloS one, 10(3), e0118703-e0118703 (2015-03-27)
Chronic renal failure is characterized by progressive renal scarring and accelerated arteriosclerotic cardiovascular disease despite what is considered to be adequate hemodialysis or peritoneal dialysis. In rodents with reduced renal mass, renal scarring has been attributed to poorly filtered, small
M El Fray et al.
Materials science & engineering. C, Materials for biological applications, 53, 15-22 (2015-06-05)
In this work, we present new nanocomposite materials derived from segmented copolyesters, comprising ethylene terephthalate (PET) segments and dimerized linoleic acid (DLA), and nanometric cerium oxide particles (CeO2). Nanoparticles were incorporated in situ during polycondensation in various concentrations, from 0.1
Adhesion to type V collagen enhances staurosporine-induced apoptosis of adrenocortical cancer cells.
Tiziana Nardo et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(10), 9949-9955 (2014-07-10)
Adrenocortical carcinoma (ACC) is a rare and aggressive tumor characterized by poor prognosis and resistance to conventional chemotherapy. Many chemotherapy agents act determining apoptosis, therefore, studying the responsiveness of ACC to apoptosis inducing molecules, can help to identify possible conditions
Tao Li et al.
Journal of cellular biochemistry, 115(10), 1683-1691 (2014-05-08)
MiRNAs have been identified in various plants and animals where they function in post-transcriptional regulation. Although studies revealed that dexamethasone play a pivotal role in the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs), the identification of specific
Derek H Rosenzweig et al.
International journal of molecular sciences, 15(8), 14427-14441 (2014-09-10)
Osteoarthritis (OA) is a debilitating joint disorder resulting from an incompletely understood combination of mechanical, biological, and biochemical processes. OA is often accompanied by inflammation and pain, whereby cytokines associated with chronic OA can up-regulate expression of neurotrophic factors such
Angélica Maciel Gomes et al.
Journal of cellular biochemistry, 116(8), 1668-1679 (2015-03-05)
The development of the mammary gland involves formation of a branched arboreal structure resulting from the penetration and proliferation of epithelial cells into the fat pad. The mammary cells invade by remodeling their surrounding extracellular matrix (ECM), which are rich
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