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Josefine Tratwal et al.
BMC molecular biology, 15, 11-11 (2014-06-03)
Human mesenchymal stromal cells from the bone marrow (BMSCs) are widely used as experimental regenerative treatment of ischemic heart disease, and the first clinical trials using adipose-derived stromal cells (ASCs) are currently being conducted. Regenerative mechanisms of BMSCs and ASCs
Margherita Eufemi et al.
Neurochemistry international, 81, 48-56 (2015-01-31)
Microglia are macrophages within the central nervous system playing a central role in neurodegenerative disorders. Although the initial engagement of microglia seems to be neuroprotective, many lines of evidence indicate that its persistent activation contributes to dismantle neuronal activity and
Eman Y Gohar et al.
PloS one, 9(4), e95079-e95079 (2014-04-16)
We investigated the effect of chronic nicotine on cholinergically-mediated renal vasodilations in female rats and its modulation by the nitric oxide synthase (NOS)/heme oxygenase (HO) pathways. Dose-vasodilatory response curves of acetylcholine (0.01-2.43 nmol) were established in isolated phenylephrine-preconstricted perfused kidneys
Yu-Juei Hsu et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(1), 116-127 (2014-07-06)
Inactivation of the thiazide-sensitive sodium chloride cotransporter (NCC) due to genetic mutations in Gitelman's syndrome (GS) or pharmacological inhibition with thiazide diuretics causes hypocalciuria and increased bone mineral density (BMD) with unclear extrarenal calcium (Ca(2+) ) regulation. We investigated intestinal
Hercules Antônio da Silva-Souza et al.
Biochimica et biophysica acta, 1838(7), 1967-1977 (2014-04-20)
We have previously described that arachidonic acid (AA)-5-lipoxygenase (5-LO) metabolism inhibitors such as NDGA and MK886, inhibit cell death by apoptosis, but not by necrosis, induced by extracellular ATP (ATPe) binding to P2X7 receptors in macrophages. ATPe binding to P2X7
Fang Niu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(35), 11812-11825 (2014-08-29)
In the era of antiretroviral therapy, although the human immunodeficiency virus (HIV) replication can be successfully controlled, complications of the CNS continue to affect infected individuals. Viral Tat protein is not only neurotoxic but has also been shown to disrupt
You-Min Lin et al.
PloS one, 9(9), e106242-e106242 (2014-09-03)
Inflammatory infiltrates and pro-inflammatory mediators are found increased in obstructive and functional bowel disorders, in which lumen distention is present. However, what caused the low level inflammation is not well known. We tested the hypothesis that lumen distention- associated mechanical
Cesidio Giuliani et al.
PloS one, 9(9), e107936-e107936 (2014-09-25)
Resveratrol is a polyphenol found in grapes and berries that has antioxidant, antiproliferative and anti-inflammatory properties. For these reasons, it is available as a dietary supplement, and it is under investigation in several clinical trials. Few data are available regarding
Jianlong Zhao et al.
International journal of molecular sciences, 21(10) (2020-05-21)
Plant-parasitic nematodes secrete a series of effectors to promote parasitism by modulating host immunity, but the detailed molecular mechanism is ambiguous. Animal parasites secrete macrophage migration inhibitory factor (MIF)-like proteins for evasion of host immune systems, in which their biochemical
Y Chen et al.
Transplantation proceedings, 46(5), 1649-1657 (2014-06-18)
The efficacy of any bioartificial liver device requires both rapid production and proper bioactivity of the cells for the bioreactor. The goal of this study was to observe the effect of spinner speed and cell density on the proliferation of
A L Zanatta et al.
Lipids, 49(7), 665-675 (2014-05-27)
Dietary fish oil supplementation increases the content of n-3 polyunsaturated fatty acids (PUFA) in cellular membranes. The highly unsaturated nature of n-3 PUFA could result in an enhanced lipid peroxidation in the oxidative environment characteristic of asthma. The oxidative reaction
Koichi Hirata et al.
PLoS neglected tropical diseases, 8(8), e3085-e3085 (2014-08-29)
The voltage-sensitive sodium (Na+) channel (Vssc) is the target site of pyrethroid insecticides. Pest insects develop resistance to this class of insecticide by acquisition of one or multiple amino acid substitution(s) in this channel. In Southeast Asia, two major Vssc
Kathryn Ball et al.
Biopharmaceutics & drug disposition, 35(8), 485-499 (2014-07-22)
The prediction of brain extracellular fluid (ECF) concentrations in human is a potentially valuable asset during drug development as it can provide the pharmacokinetic input for pharmacokinetic-pharmacodynamic models. This study aimed to compare two translational modelling approaches that can be
Kazuhiko Yamamura et al.
The Journal of dermatology, 41(9), 808-814 (2014-08-27)
We previously reported that the addition of orally administered yokukansan (YKS), a traditional Japanese herbal medicine, to the standard regimen using histamine H1-receptor inhibitors was effective in controlling refractory chronic urticaria, but the mechanism remained unknown. YKS has also been
Christine Kowalczyk-Quintas et al.
The Journal of investigative dermatology, 135(2), 359-368 (2014-09-11)
Impaired ectodysplasin A (EDA) receptor (EDAR) signaling affects ectodermally derived structures including teeth, hair follicles, and cutaneous glands. The X-linked hypohidrotic ectodermal dysplasia (XLHED), resulting from EDA deficiency, can be rescued with lifelong benefits in animal models by stimulation of
Ashraf A Sabe et al.
Journal of medicinal food, 18(1), 60-66 (2014-08-05)
Resveratrol has been shown to improve cardiac perfusion and ventricular function after chronic ischemic injury. Using proteomic analysis, we sought to objectively investigate potential mechanisms, by which resveratrol exerts its cardioprotective effects in the setting of metabolic syndrome and chronic
Grégory Chatelain et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(3), 497-507 (2014-12-24)
Bone is the main target organ for the storage of several toxic metals, including uranium. But the mode of action of uranium on bones remains poorly understood. To better assess the impact of uranium on bone cells, synthetic biomimetic apatites
Stanley Ka-Lok Li et al.
Investigative ophthalmology & visual science, 56(2), 1396-1405 (2015-02-07)
Aqueous humor inflow falls 50% during sleeping hours without proportional fall in IOP, partly reflecting reduced outflow facility. The mechanisms underlying outflow facility cycling are unknown. One outflow facility regulator is matrix metalloproteinase (MMP) release from trabecular meshwork (TM) cells.
Caterina Peraldo-Neia et al.
BMC cancer, 14, 918-918 (2014-12-07)
Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line chemotherapy is demonstrated to be effective. Thus, there is an urgent need to
S Matsumura et al.
Oral diseases, 21(3), 361-372 (2014-09-03)
The characteristics of cell populations extracted from oral mucosal non-epithelial tissues and their ability to differentiate were evaluated in vitro as a potential source of cells for mandibular and corneal regeneration. Oral mucosal non-epithelial cells (OMNECs) were extracted from tissue
Marisa Freitas et al.
European journal of medicinal chemistry, 86, 153-164 (2014-08-26)
Neutrophils are considered the central cells of acute inflammation. Flavonoids have been suggested as therapeutic agents to avoid damages induced by inflammatory processes. It is well known the reactivity of flavonoids with hypochlorous acid produced by neutrophils, to form stable
Yusuke Kumai et al.
Pflugers Archiv : European journal of physiology, 467(4), 753-765 (2014-06-05)
The present study investigated the role of the transcription factor, glial cell missing 2 (gcm2), in Ca(2+) regulation in zebrafish larvae. Translational gene knockdown of gcm2 decreased Ca(2+) uptake and the density of ionocytes expressing the epithelial Ca(2+) channel (ecac)
Yanbo Yang et al.
Lipids, 49(6), 505-515 (2014-04-30)
Hepatic lipase (HL) and endothelial lipase (EL) share overlapping and complementary roles in lipoprotein metabolism. The deletion of HL and EL alleles in mice raises plasma total cholesterol and phospholipid concentrations. However, the influence of HL and EL in vivo
D Mehra et al.
Molecular pharmacology, 86(6), 696-706 (2014-10-03)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) causes sudden cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin. Flecainide, a class I antiarrhythmic drug, inhibits Na(+) and RyR2 channels and prevents CPVT. The purpose of this study is
N Singh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 968, 105-111 (2014-04-08)
SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that modulate SIRT6 activity could be of great therapeutic importance. We have
Helena Lindgren et al.
PloS one, 10(3), e0119143-e0119143 (2015-03-11)
Francisella tularensis is a highly virulent facultative intracellular pathogen causing the severe disease tularemia in mammals. As for other bacteria, iron is essential for its growth but very few mechanisms for iron acquisition have been identified. Here, we analyzed if
Chih-Jen Cheng et al.
American journal of physiology. Renal physiology, 308(5), F437-F443 (2014-12-06)
SPAK [STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase] kinase consists of a full-length (FL-) and an alternatively spliced kidney-specific (KS-) isoform. SPAK regulates the NaCl cotransporter (NCC) in the distal convoluted tubule (DCT). The relative abundance and role of FL- vs. KS-SPAK
Richard D Collage et al.
Critical care medicine, 41(11), e352-e360 (2013-07-28)
Calcium plays an essential role in nearly all cellular processes. As such, cellular and systemic calcium concentrations are tightly regulated. During sepsis, derangements in such tight regulation frequently occur, and treating hypocalcemia with parenteral calcium administration remains the current practice
Paola Devoto et al.
Addiction biology, 19(4), 612-622 (2013-01-08)
The dopamine-beta-hydroxylase inhibitor nepicastat has been shown to reproduce disulfiram ability to suppress the reinstatement of cocaine seeking after extinction in rats. To clarify its mechanism of action, we examined the effect of nepicastat, given alone or in association with
Jiejun Shi et al.
Nucleic acids research, 42(15), 9730-9739 (2014-08-02)
ATP-dependent chromatin remodeling complexes regulate nucleosome organizations. In Drosophila, gene Brm encodes the core Brahma complex, the ATPase subunit of SWI/SNF class of chromatin remodelers. Its role in modulating the nucleosome landscape in vivo is unclear. In this study, we
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